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Targeted pharmacological therapy restores β-cell function for diabetes remission.
Sachs S, Bastidas-Ponce A, Tritschler S, Bakhti M, Böttcher A, Sánchez-Garrido MA, Tarquis-Medina M, Kleinert M, Fischer K, Jall S, Harger A, Bader E, Roscioni S, Ussar S, Feuchtinger A, Yesildag B, Neelakandhan A, Jensen CB, Cornu M, Yang B, Finan B, DiMarchi RD, Tschöp MH, Theis FJ, Hofmann SM, Müller TD, Lickert H. Sachs S, et al. Nat Metab. 2020 Feb;2(2):192-209. doi: 10.1038/s42255-020-0171-3. Epub 2020 Feb 20. Nat Metab. 2020. PMID: 32694693
A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.
Chhabra NF, Amend AL, Bastidas-Ponce A, Sabrautzki S, Tarquis-Medina M, Sachs S, Rubey M, Lorenz-Depiereux B, Feuchtinger A, Bakhti M, Lickert H, Przemeck GKH, Hrabě de Angelis M. Chhabra NF, et al. Among authors: sachs s. Mol Metab. 2021 Dec;54:101334. doi: 10.1016/j.molmet.2021.101334. Epub 2021 Sep 4. Mol Metab. 2021. PMID: 34487921 Free PMC article.
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.
Clemmensen C, Jall S, Kleinert M, Quarta C, Gruber T, Reber J, Sachs S, Fischer K, Feuchtinger A, Karlas A, Simonds SE, Grandl G, Loher D, Sanchez-Quant E, Keipert S, Jastroch M, Hofmann SM, Nascimento EBM, Schrauwen P, Ntziachristos V, Cowley MA, Finan B, Müller TD, Tschöp MH. Clemmensen C, et al. Among authors: sachs s. Nat Commun. 2018 Oct 23;9(1):4304. doi: 10.1038/s41467-018-06769-y. Nat Commun. 2018. PMID: 30353008 Free PMC article.
Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans.
Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, Newsom SA, Strauss A, Kerege A, Schoen JA, Bessesen DH, Schwarzmayr T, Graf E, Lutter D, Krumsiek J, Hofmann SM, Bergman BC. Sachs S, et al. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E866-E879. doi: 10.1152/ajpendo.00243.2018. Epub 2019 Jan 8. Am J Physiol Endocrinol Metab. 2019. PMID: 30620635 Free PMC article.
Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.
Jall S, De Angelis M, Lundsgaard AM, Fritzen AM, Nicolaisen TS, Klein AB, Novikoff A, Sachs S, Richter EA, Kiens B, Schramm KW, Tschöp MH, Stemmer K, Clemmensen C, Müller TD, Kleinert M. Jall S, et al. Among authors: sachs s. Diabetologia. 2020 Jun;63(6):1236-1247. doi: 10.1007/s00125-020-05117-4. Epub 2020 Mar 6. Diabetologia. 2020. PMID: 32140744 Free PMC article.
Circulating HDL levels control hypothalamic astrogliosis via apoA-I.
Götz A, Lehti M, Donelan E, Striese C, Cucuruz S, Sachs S, Yi CX, Woods SC, Wright SD, Müller TD, Tschöp MH, Gao Y, Hofmann SM. Götz A, et al. Among authors: sachs s. J Lipid Res. 2018 Sep;59(9):1649-1659. doi: 10.1194/jlr.M085456. Epub 2018 Jul 10. J Lipid Res. 2018. PMID: 29991652 Free PMC article.
Glucagon Regulation of Energy Expenditure.
Kleinert M, Sachs S, Habegger KM, Hofmann SM, Müller TD. Kleinert M, et al. Among authors: sachs s. Int J Mol Sci. 2019 Oct 30;20(21):5407. doi: 10.3390/ijms20215407. Int J Mol Sci. 2019. PMID: 31671603 Free PMC article. Review.
181 results