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Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation.
Leal LF, Szarek E, Berthon A, Nesterova M, Faucz FR, London E, Mercier C, Abu-Asab M, Starost MF, Dye L, Bilinska B, Kotula-Balak M, Antonini SR, Stratakis CA. Leal LF, et al. Among authors: starost mf. Mol Cell Endocrinol. 2021 Feb 15;522:111117. doi: 10.1016/j.mce.2020.111117. Epub 2020 Dec 15. Mol Cell Endocrinol. 2021. PMID: 33338547
Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling.
Almeida MQ, Muchow M, Boikos S, Bauer AJ, Griffin KJ, Tsang KM, Cheadle C, Watkins T, Wen F, Starost MF, Bossis I, Nesterova M, Stratakis CA. Almeida MQ, et al. Among authors: starost mf. Hum Mol Genet. 2010 Apr 15;19(8):1387-98. doi: 10.1093/hmg/ddq014. Epub 2010 Jan 15. Hum Mol Genet. 2010. PMID: 20080939 Free PMC article.
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Tsang KM, Starost MF, Nesterova M, Boikos SA, Watkins T, Almeida MQ, Harran M, Li A, Collins MT, Cheadle C, Mertz EL, Leikin S, Kirschner LS, Robey P, Stratakis CA. Tsang KM, et al. Among authors: starost mf. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8683-8. doi: 10.1073/pnas.1003680107. Epub 2010 Apr 26. Proc Natl Acad Sci U S A. 2010. PMID: 20421483 Free PMC article.
Hematopoietic neoplasms in Prkar2a-deficient mice.
Saloustros E, Salpea P, Qi CF, Gugliotti LA, Tsang K, Liu S, Starost MF, Morse HC 3rd, Stratakis CA. Saloustros E, et al. Among authors: starost mf. J Exp Clin Cancer Res. 2015 Nov 25;34:143. doi: 10.1186/s13046-015-0257-z. J Exp Clin Cancer Res. 2015. PMID: 26608815 Free PMC article.
Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis.
Saloustros E, Salpea P, Starost M, Liu S, Faucz FR, London E, Szarek E, Song WJ, Hussain M, Stratakis CA. Saloustros E, et al. Endocr Relat Cancer. 2017 Jan;24(1):31-40. doi: 10.1530/ERC-16-0443. Epub 2016 Nov 1. Endocr Relat Cancer. 2017. PMID: 27803029 Free PMC article.
93 results