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Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, Ali L, Saito T, Guillermier C, Saido TC, Steinhauser ML, Stowell MHB, Chapman ER, Contractor A, Savas JN. Hark TJ, et al. Cell Syst. 2021 Feb 17;12(2):141-158.e9. doi: 10.1016/j.cels.2020.11.007. Epub 2020 Dec 15. Cell Syst. 2021. PMID: 33326751 Free PMC article.
Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology.
Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, Ghosh A, Yates JR 3rd. Savas JN, et al. Among authors: hark tj. Cell Rep. 2017 Nov 28;21(9):2614-2627. doi: 10.1016/j.celrep.2017.11.009. Cell Rep. 2017. PMID: 29186695 Free PMC article.
Long-lived mitochondrial cristae proteins in mouse heart and brain.
Bomba-Warczak E, Edassery SL, Hark TJ, Savas JN. Bomba-Warczak E, et al. Among authors: hark tj. J Cell Biol. 2021 Sep 6;220(9):e202005193. doi: 10.1083/jcb.202005193. Epub 2021 Jul 14. J Cell Biol. 2021. PMID: 34259807 Free PMC article.
Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
Tsioras K, Smith KC, Edassery SL, Garjani M, Li Y, Williams C, McKenna ED, Guo W, Wilen AP, Hark TJ, Marklund SL, Ostrow LW, Gilthorpe JD, Ichida JK, Kalb RG, Savas JN, Kiskinis E. Tsioras K, et al. Among authors: hark tj. Cell Rep. 2023 Oct 31;42(10):113160. doi: 10.1016/j.celrep.2023.113160. Epub 2023 Sep 29. Cell Rep. 2023. PMID: 37776851 Free PMC article.