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Therapeutic genetic variation revealed in diverse Hsp104 homologs.
March ZM, Sweeney K, Kim H, Yan X, Castellano LM, Jackrel ME, Lin J, Chuang E, Gomes E, Willicott CW, Michalska K, Jedrzejczak RP, Joachimiak A, Caldwell KA, Caldwell GA, Shalem O, Shorter J. March ZM, et al. Among authors: yan x. Elife. 2020 Dec 15;9:e57457. doi: 10.7554/eLife.57457. Elife. 2020. PMID: 33319748 Free PMC article.
Calcineurin determines toxic versus beneficial responses to α-synuclein.
Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Ben-Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, Lindquist S. Caraveo G, et al. Among authors: yan x. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3544-52. doi: 10.1073/pnas.1413201111. Epub 2014 Aug 13. Proc Natl Acad Sci U S A. 2014. PMID: 25122673 Free PMC article.
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.
Knight AL, Yan X, Hamamichi S, Ajjuri RR, Mazzulli JR, Zhang MW, Daigle JG, Zhang S, Borom AR, Roberts LR, Lee SK, DeLeon SM, Viollet-Djelassi C, Krainc D, O'Donnell JM, Caldwell KA, Caldwell GA. Knight AL, et al. Among authors: yan x. Cell Metab. 2014 Jul 1;20(1):145-57. doi: 10.1016/j.cmet.2014.04.017. Epub 2014 May 29. Cell Metab. 2014. PMID: 24882066 Free PMC article.
Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.
Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. Chang CY, et al. Among authors: yan x. Biochemistry. 2018 Jun 12;57(23):3278-3288. doi: 10.1021/acs.biochem.8b00174. Epub 2018 Mar 21. Biochemistry. 2018. PMID: 29533601 Free PMC article.
Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.
Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, Joachimiak A, Phillips GN, Shen B. Huang T, et al. Among authors: yan x. J Antibiot (Tokyo). 2016 Oct;69(10):731-740. doi: 10.1038/ja.2016.88. Epub 2016 Jul 13. J Antibiot (Tokyo). 2016. PMID: 27406907 Free PMC article.
Resistance to Enediyne Antitumor Antibiotics by Sequestration.
Chang CY, Yan X, Crnovcic I, Annaval T, Chang C, Nocek B, Rudolf JD, Yang D, Hindra, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. Chang CY, et al. Among authors: yan x. Cell Chem Biol. 2018 Sep 20;25(9):1075-1085.e4. doi: 10.1016/j.chembiol.2018.05.012. Epub 2018 Jun 21. Cell Chem Biol. 2018. PMID: 29937405 Free PMC article.
Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN Jr, Shen B. Chang CY, et al. Among authors: yan x. Biochemistry. 2016 Sep 13;55(36):5142-54. doi: 10.1021/acs.biochem.6b00713. Epub 2016 Sep 1. Biochemistry. 2016. PMID: 27560143 Free PMC article.
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