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A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death.
Ceder S, Eriksson SE, Cheteh EH, Dawar S, Corrales Benitez M, Bykov VJN, Fujihara KM, Grandin M, Li X, Ramm S, Behrenbruch C, Simpson KJ, Hollande F, Abrahmsen L, Clemons NJ, Wiman KG. Ceder S, et al. Among authors: simpson kj. EMBO Mol Med. 2021 Feb 5;13(2):e10852. doi: 10.15252/emmm.201910852. Epub 2020 Dec 14. EMBO Mol Med. 2021. PMID: 33314700 Free PMC article.
High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids.
Choo N, Ramm S, Luu J, Winter JM, Selth LA, Dwyer AR, Frydenberg M, Grummet J, Sandhu S, Hickey TE, Tilley WD, Taylor RA, Risbridger GP, Lawrence MG, Simpson KJ. Choo N, et al. Among authors: simpson kj. SLAS Discov. 2021 Oct;26(9):1107-1124. doi: 10.1177/24725552211020668. Epub 2021 Jun 11. SLAS Discov. 2021. PMID: 34111999 Free PMC article.
CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition.
Lawrence MG, Porter LH, Choo N, Pook D, Grummet JP, Pezaro CJ, Sandhu S, Ramm S, Luu J, Bakshi A, Goode DL, Sanij E, Pearson RB, Hannan RD, Simpson KJ, Taylor RA, Risbridger GP, Furic L. Lawrence MG, et al. Among authors: simpson kj. Mol Cancer Ther. 2021 Nov;20(11):2140-2150. doi: 10.1158/1535-7163.MCT-20-0932. Epub 2021 Aug 19. Mol Cancer Ther. 2021. PMID: 34413130
Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction.
Fujihara KM, Zhang BZ, Jackson TD, Ogunkola MO, Nijagal B, Milne JV, Sallman DA, Ang CS, Nikolic I, Kearney CJ, Hogg SJ, Cabalag CS, Sutton VR, Watt S, Fujihara AT, Trapani JA, Simpson KJ, Stojanovski D, Leimkühler S, Haupt S, Phillips WA, Clemons NJ. Fujihara KM, et al. Among authors: simpson kj. Sci Adv. 2022 Sep 16;8(37):eabm9427. doi: 10.1126/sciadv.abm9427. Epub 2022 Sep 14. Sci Adv. 2022. PMID: 36103522 Free PMC article.
Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling.
Pillay V, Shukla L, Herle P, Maciburko S, Bandara N, Reid I, Morgan S, Yuan Y, Luu J, Cowley KJ, Ramm S, Simpson KJ, Achen MG, Stacker SA, Shayan R, Karnezis T. Pillay V, et al. Among authors: simpson kj. Front Pharmacol. 2023 Apr 28;14:1152314. doi: 10.3389/fphar.2023.1152314. eCollection 2023. Front Pharmacol. 2023. PMID: 37188266 Free PMC article.
High-throughput approaches to measuring cell death.
Saunders DN, Falkenberg KJ, Simpson KJ. Saunders DN, et al. Among authors: simpson kj. Cold Spring Harb Protoc. 2014 Jun 2;2014(6):591-601. doi: 10.1101/pdb.top072561. Cold Spring Harb Protoc. 2014. PMID: 24890217
289 results