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Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts.
Krishna V, Yin X, Song Q, Walsh A, Pocalyko D, Bachman K, Anderson I, Madakamutil L, Nagpal S. Krishna V, et al. Among authors: nagpal s. J Immunol. 2021 Jan 15;206(2):422-431. doi: 10.4049/jimmunol.2000286. Epub 2020 Dec 7. J Immunol. 2021. PMID: 33288543
Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus.
Cole S, Walsh A, Yin X, Wechalekar MD, Smith MD, Proudman SM, Veale DJ, Fearon U, Pitzalis C, Humby F, Bombardieri M, Axel A, Adams H 3rd, Chiu C, Sharp M, Alvarez J, Anderson I, Madakamutil L, Nagpal S, Guo Y. Cole S, et al. Among authors: nagpal s. Arthritis Res Ther. 2018 May 2;20(1):85. doi: 10.1186/s13075-018-1578-z. Arthritis Res Ther. 2018. PMID: 29720240 Free PMC article.
Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes.
Ai R, Laragione T, Hammaker D, Boyle DL, Wildberg A, Maeshima K, Palescandolo E, Krishna V, Pocalyko D, Whitaker JW, Bai Y, Nagpal S, Bachman KE, Ainsworth RI, Wang M, Ding B, Gulko PS, Wang W, Firestein GS. Ai R, et al. Among authors: nagpal s. Nat Commun. 2018 May 15;9(1):1921. doi: 10.1038/s41467-018-04310-9. Nat Commun. 2018. PMID: 29765031 Free PMC article.
Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.
Guo Y, Walsh AM, Canavan M, Wechalekar MD, Cole S, Yin X, Scott B, Loza M, Orr C, McGarry T, Bombardieri M, Humby F, Proudman SM, Pitzalis C, Smith MD, Friedman JR, Anderson I, Madakamutil L, Veale DJ, Fearon U, Nagpal S. Guo Y, et al. Among authors: nagpal s. PLoS One. 2018 Feb 28;13(2):e0192704. doi: 10.1371/journal.pone.0192704. eCollection 2018. PLoS One. 2018. PMID: 29489833 Free PMC article.
Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis.
Floudas A, Smith CM, Tynan O, Neto N, Krishna V, Wade SM, Hanlon M, Cunningham C, Marzaioli V, Canavan M, Fletcher JM, Mullan RH, Cole S, Hao LY, Monaghan MG, Nagpal S, Veale DJ, Fearon U. Floudas A, et al. Among authors: nagpal s. Ann Rheum Dis. 2022 Aug 11;81(9):1224-1242. doi: 10.1136/annrheumdis-2021-221761. Ann Rheum Dis. 2022. PMID: 35701153 Free article.
Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease.
McGarry T, Hanlon MM, Marzaioli V, Cunningham CC, Krishna V, Murray K, Hurson C, Gallagher P, Nagpal S, Veale DJ, Fearon U. McGarry T, et al. Among authors: nagpal s. Clin Transl Immunology. 2021 Jan 19;10(1):e1237. doi: 10.1002/cti2.1237. eCollection 2021. Clin Transl Immunology. 2021. PMID: 33510894 Free PMC article.
Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint.
Floudas A, Neto N, Marzaioli V, Murray K, Moran B, Monaghan MG, Low C, Mullan RH, Rao N, Krishna V, Nagpal S, Veale DJ, Fearon U. Floudas A, et al. Among authors: nagpal s. JCI Insight. 2020 Nov 5;5(21):e139032. doi: 10.1172/jci.insight.139032. JCI Insight. 2020. PMID: 33148884 Free PMC article.
524 results