Steyn AJC - Search Results

1

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis.

Lee BS, Hards K, Engelhart CA, Hasenoehrl EJ, Kalia NP, Mackenzie JS, Sviriaeva E, Chong SMS, Manimekalai MSS, Koh VH, Chan J, Xu J, Alonso S, Miller MJ, Steyn AJC, Grüber G, Schnappinger D, Berney M, Cook GM, Moraski GC, Pethe K. Lee BS, et al. Among authors: steyn ajc. EMBO Mol Med. 2021 Jan 11;13(1):e13207. doi: 10.15252/emmm.202013207. Epub 2020 Dec 7. EMBO Mol Med. 2021. PMID: 33283973 Free PMC article.

2

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.

Lamprecht DA, Finin PM, Rahman MA, Cumming BM, Russell SL, Jonnala SR, Adamson JH, Steyn AJ. Lamprecht DA, et al. Nat Commun. 2016 Aug 10;7:12393. doi: 10.1038/ncomms12393. Nat Commun. 2016. PMID: 27506290 Free PMC article.

3

Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c.

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V, Warner DF. Moosa A, et al. Among authors: steyn ajc. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e01338-17. doi: 10.1128/AAC.01338-17. Print 2017 Oct. Antimicrob Agents Chemother. 2017. PMID: 28760899 Free PMC article.

4

RbpA and σ^B association regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance.

Wang Z, Cumming BM, Mao C, Zhu Y, Lu P, Steyn AJC, Chen S, Hu Y. Wang Z, et al. Among authors: steyn ajc. Mol Microbiol. 2018 Jun;108(6):627-640. doi: 10.1111/mmi.13952. Epub 2018 Apr 6. Mol Microbiol. 2018. PMID: 29575247 Free article.

5

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis.

Foo CS, Lupien A, Kienle M, Vocat A, Benjak A, Sommer R, Lamprecht DA, Steyn AJC, Pethe K, Piton J, Altmann KH, Cole ST. Foo CS, et al. Among authors: steyn ajc. mBio. 2018 Oct 9;9(5):e01276-18. doi: 10.1128/mBio.01276-18. mBio. 2018. PMID: 30301850 Free PMC article.

6

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis.

Lupien A, Foo CS, Savina S, Vocat A, Piton J, Monakhova N, Benjak A, Lamprecht DA, Steyn AJC, Pethe K, Makarov VA, Cole ST. Lupien A, et al. Among authors: steyn ajc. PLoS Pathog. 2020 Jan 23;16(1):e1008270. doi: 10.1371/journal.ppat.1008270. eCollection 2020 Jan. PLoS Pathog. 2020. PMID: 31971990 Free PMC article.

7

Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis.

Saini V, Chinta KC, Reddy VP, Glasgow JN, Stein A, Lamprecht DA, Rahman MA, Mackenzie JS, Truebody BE, Adamson JH, Kunota TTR, Bailey SM, Moellering DR, Lancaster JR Jr, Steyn AJC. Saini V, et al. Among authors: steyn ajc. Nat Commun. 2020 Jan 28;11(1):557. doi: 10.1038/s41467-019-14132-y. Nat Commun. 2020. PMID: 31992699 Free PMC article.

8

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis.

Mackenzie JS, Lamprecht DA, Asmal R, Adamson JH, Borah K, Beste DJV, Lee BS, Pethe K, Rousseau S, Krieger I, Sacchettini JC, Glasgow JN, Steyn AJC. Mackenzie JS, et al. Among authors: steyn ajc. Nat Commun. 2020 Nov 30;11(1):6092. doi: 10.1038/s41467-020-19959-4. Nat Commun. 2020. PMID: 33257709 Free PMC article.

9

Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase.

Cai Y, Jaecklein E, Mackenzie JS, Papavinasasundaram K, Olive AJ, Chen X, Steyn AJC, Sassetti CM. Cai Y, et al. Among authors: steyn ajc. PLoS Pathog. 2021 Jul 28;17(7):e1008911. doi: 10.1371/journal.ppat.1008911. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34320028 Free PMC article.

10

Mycobacterium tuberculosis H₂S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility.

Kunota TTR, Rahman MA, Truebody BE, Mackenzie JS, Saini V, Lamprecht DA, Adamson JH, Sevalkar RR, Lancaster JR Jr, Berney M, Glasgow JN, Steyn AJC. Kunota TTR, et al. Among authors: steyn ajc. Antioxidants (Basel). 2021 Aug 13;10(8):1285. doi: 10.3390/antiox10081285. Antioxidants (Basel). 2021. PMID: 34439535 Free PMC article.

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