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Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis.
Lee BS, Hards K, Engelhart CA, Hasenoehrl EJ, Kalia NP, Mackenzie JS, Sviriaeva E, Chong SMS, Manimekalai MSS, Koh VH, Chan J, Xu J, Alonso S, Miller MJ, Steyn AJC, Grüber G, Schnappinger D, Berney M, Cook GM, Moraski GC, Pethe K. Lee BS, et al. Among authors: schnappinger d. EMBO Mol Med. 2021 Jan 11;13(1):e13207. doi: 10.15252/emmm.202013207. Epub 2020 Dec 7. EMBO Mol Med. 2021. PMID: 33283973 Free PMC article.
A broader spectrum of tuberculosis.
Schnappinger D, Ehrt S. Schnappinger D, et al. Nat Med. 2016 Oct 6;22(10):1076-1077. doi: 10.1038/nm.4186. Nat Med. 2016. PMID: 27711059 No abstract available.
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SW, Ioerger TR, Schnappinger D, Ehrt S. Xu W, et al. Among authors: schnappinger d. Antimicrob Agents Chemother. 2017 Nov 22;61(12):e01334-17. doi: 10.1128/AAC.01334-17. Print 2017 Dec. Antimicrob Agents Chemother. 2017. PMID: 28893793 Free PMC article.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, Dartois V, Schnappinger D. Tiwari D, et al. Among authors: schnappinger d. Sci Transl Med. 2018 Apr 25;10(438):eaal1803. doi: 10.1126/scitranslmed.aal1803. Sci Transl Med. 2018. PMID: 29695454 Free PMC article.
Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
Oh S, Park Y, Engelhart CA, Wallach JB, Schnappinger D, Arora K, Manikkam M, Gac B, Wang H, Murgolo N, Olsen DB, Goodwin M, Sutphin M, Weiner DM, Via LE, Boshoff HIM, Barry CE 3rd. Oh S, et al. Among authors: schnappinger d. J Med Chem. 2018 Nov 21;61(22):9952-9965. doi: 10.1021/acs.jmedchem.8b00883. Epub 2018 Nov 5. J Med Chem. 2018. PMID: 30350998 Free PMC article.
Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase.
Bockman MR, Engelhart CA, Cramer JD, Howe MD, Mishra NK, Zimmerman M, Larson P, Alvarez-Cabrera N, Park SW, Boshoff HIM, Bean JM, Young VG Jr, Ferguson DM, Dartois V, Jarrett JT, Schnappinger D, Aldrich CC. Bockman MR, et al. Among authors: schnappinger d. ACS Infect Dis. 2019 Apr 12;5(4):598-617. doi: 10.1021/acsinfecdis.8b00345. Epub 2019 Feb 4. ACS Infect Dis. 2019. PMID: 30652474 Free PMC article.
133 results