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Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control.
Salpini R, Alkhatib M, Costa G, Piermatteo L, Ambrosio FA, Di Maio VC, Scutari R, Duca L, Berno G, Fabeni L, Alcaro S, Ceccherini-Silberstein F, Artese A, Svicher V. Salpini R, et al. Among authors: artese a. J Antimicrob Chemother. 2021 Jan 19;76(2):396-412. doi: 10.1093/jac/dkaa444. J Antimicrob Chemother. 2021. PMID: 33254234 Free PMC article.
Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold.
Alcaro S, Artese A, Iley JN, Maccari R, Missailidis S, Ortuso F, Ottanà R, Ragazzon P, Vigorita MG. Alcaro S, et al. Among authors: artese a. Bioorg Med Chem Lett. 2007 May 1;17(9):2509-14. doi: 10.1016/j.bmcl.2007.02.022. Epub 2007 Feb 9. Bioorg Med Chem Lett. 2007. PMID: 17317164
Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of resistance to nonnucleoside inhibitors.
Ceccherini-Silberstein F, Svicher V, Sing T, Artese A, Santoro MM, Forbici F, Bertoli A, Alcaro S, Palamara G, d'Arminio Monforte A, Balzarini J, Antinori A, Lengauer T, Perno CF. Ceccherini-Silberstein F, et al. Among authors: artese a. J Virol. 2007 Oct;81(20):11507-19. doi: 10.1128/JVI.00303-07. Epub 2007 Aug 8. J Virol. 2007. PMID: 17686836 Free PMC article.
Specific enfuvirtide-associated mutational pathways in HIV-1 Gp41 are significantly correlated with an increase in CD4(+) cell count, despite virological failure.
Svicher V, Aquaro S, D'Arrigo R, Artese A, Dimonte S, Alcaro S, Santoro MM, Di Perri G, Caputo SL, Bellagamba R, Zaccarelli M, Visco-Comandini U, Antinori A, Narciso P, Ceccherini-Silberstein F, Perno CF. Svicher V, et al. Among authors: artese a. J Infect Dis. 2008 May 15;197(10):1408-18. doi: 10.1086/587693. J Infect Dis. 2008. PMID: 18419549
Computational analysis of Human Immunodeficiency Virus (HIV) Type-1 reverse transcriptase crystallographic models based on significant conserved residues found in Highly Active Antiretroviral Therapy (HAART)-treated patients.
Alcaro S, Artese A, Ceccherini-Silberstein F, Chiarella V, Dimonte S, Ortuso F, Perno CF. Alcaro S, et al. Among authors: artese a. Curr Med Chem. 2010;17(4):290-308. doi: 10.2174/092986710790192695. Curr Med Chem. 2010. PMID: 20015046 Review.
Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens.
Svicher V, Alteri C, Artese A, Forbici F, Santoro MM, Schols D, Van Laethem K, Alcaro S, Costa G, Tommasi C, Zaccarelli M, Narciso P, Antinori A, Ceccherini-Silberstein F, Balzarini J, Perno CF. Svicher V, et al. Among authors: artese a. J Acquir Immune Defic Syndr. 2010 Nov;55(3):336-44. doi: 10.1097/QAI.0b013e3181e6763f. J Acquir Immune Defic Syndr. 2010. PMID: 20739898
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