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RAS-protein activation but not mutation status is an outcome predictor and unifying therapeutic target for high-risk acute lymphoblastic leukemia.
Oncogene. 2021 Jan;40(4):746-762. doi: 10.1038/s41388-020-01567-7. Epub 2020 Nov 27.
Oncogene. 2021.
PMID: 33247204
Free PMC article.
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, Kvartsberg H, Brinkmalm G, Hithersay R, Startin C, Hamburg S, Phillips M, Pervushin K, Turmaine M, Wallon D, Rovelet-Lecrux A, Soininen H, Volpi E, Martin JE, Foo JN, Becker DL, Rostagno A, Ghiso J, Krsnik Ž, Šimić G, Kostović I, Mitrečić D; LonDownS Consortium; Francis PT, Blennow K, Strydom A, Hardy J, Zetterberg H, Nižetić D.
Alić I, et al. Among authors: koschut d.
Mol Psychiatry. 2021 Oct;26(10):5766-5788. doi: 10.1038/s41380-020-0806-5. Epub 2020 Jul 10.
Mol Psychiatry. 2021.
PMID: 32647257
Free PMC article.
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Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, Kvartsberg H, Brinkmalm G, Hithersay R, Startin C, Hamburg S, Phillips M, Pervushin K, Turmaine M, Wallon D, Rovelet-Lecrux A, Soininen H, Volpi E, Martin JE, Foo JN, Becker DL, Rostagno A, Ghiso J, Krsnik Ž, Šimić G, Kostović I, Mitrečić D; LonDownS Consortium; Francis PT, Blennow K, Strydom A, Hardy J, Zetterberg H, Nižetić D.
Alić I, et al. Among authors: koschut d.
Mol Psychiatry. 2021 Oct;26(10):5789. doi: 10.1038/s41380-021-01206-x.
Mol Psychiatry. 2021.
PMID: 34272490
Free PMC article.
No abstract available.
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Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.
Murray A, Gough G, Cindrić A, Vučković F, Koschut D, Borelli V, Petrović DJ, Bekavac A, Plećaš A, Hribljan V, Brunmeir R, Jurić J, Pučić-Baković M, Slana A, Deriš H, Frkatović A, Groet J, O'Brien NL, Chen HY, Yeap YJ, Delom F, Havlicek S, Gammon L, Hamburg S, Startin C, D'Souza H, Mitrečić D, Kero M, Odak L, Krušlin B, Krsnik Ž, Kostović I, Foo JN, Loh YH, Dunn NR, de la Luna S, Spector T, Barišić I, Thomas MSC, Strydom A, Franceschi C, Lauc G, Krištić J, Alić I, Nižetić D.
Murray A, et al. Among authors: koschut d.
EBioMedicine. 2023 Aug;94:104692. doi: 10.1016/j.ebiom.2023.104692. Epub 2023 Jul 12.
EBioMedicine. 2023.
PMID: 37451904
Free PMC article.
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Quantitative live imaging reveals a direct interaction between CD44v6 and MET in membrane domains upon activation with both MET ligands, HGF and internalin B.
Tannoo RM, Richert L, Koschut D, Tomishige N, Treffert SM, Kobayashi T, Mély Y, Orian-Rousseau V.
Tannoo RM, et al. Among authors: koschut d.
Biochim Biophys Acta Biomembr. 2024 Jan;1866(1):184236. doi: 10.1016/j.bbamem.2023.184236. Epub 2023 Oct 2.
Biochim Biophys Acta Biomembr. 2024.
PMID: 37793560
Free article.
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Live cell imaging shows hepatocyte growth factor-induced Met dimerization.
Koschut D, Richert L, Pace G, Niemann HH, Mély Y, Orian-Rousseau V.
Koschut D, et al.
Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1552-8. doi: 10.1016/j.bbamcr.2016.04.015. Epub 2016 Apr 17.
Biochim Biophys Acta. 2016.
PMID: 27094128
Free article.
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Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6.
Volz Y, Koschut D, Matzke-Ogi A, Dietz MS, Karathanasis C, Richert L, Wagner MG, Mély Y, Heilemann M, Niemann HH, Orian-Rousseau V.
Volz Y, et al. Among authors: koschut d.
Biosci Rep. 2015 Jun 29;35(4):e00236. doi: 10.1042/BSR20150093.
Biosci Rep. 2015.
PMID: 26181364
Free PMC article.
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Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins.
Hasenauer S, Malinger D, Koschut D, Pace G, Matzke A, von Au A, Orian-Rousseau V.
Hasenauer S, et al. Among authors: koschut d.
PLoS One. 2013 Apr 23;8(4):e62357. doi: 10.1371/journal.pone.0062357. Print 2013.
PLoS One. 2013.
PMID: 23626807
Free PMC article.
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