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Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).
Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129800. doi: 10.1016/j.bbagen.2020.129800. Epub 2020 Nov 25.
Biochim Biophys Acta Gen Subj. 2021.
PMID: 33246032
Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
Luz JG, Antonysamy S, Kuklish SL, Condon B, Lee MR, Allison D, Yu XP, Chandrasekhar S, Backer R, Zhang A, Russell M, Chang SS, Harvey A, Sloan AV, Fisher MJ.
Luz JG, et al. Among authors: sloan av.
J Med Chem. 2015 Jun 11;58(11):4727-37. doi: 10.1021/acs.jmedchem.5b00330. Epub 2015 May 20.
J Med Chem. 2015.
PMID: 25961169
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Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Kuklish SL, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland AJ, Gooding K, Harvey A, Hughes NE, Luz JG, Manninen PR, McGee JE, Navarro A, Norman BH, Partridge KM, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, York JS, Yu XP.
Kuklish SL, et al. Among authors: sloan av.
Bioorg Med Chem Lett. 2016 Oct 1;26(19):4824-4828. doi: 10.1016/j.bmcl.2016.08.023. Epub 2016 Aug 10.
Bioorg Med Chem Lett. 2016.
PMID: 27554445
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Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Partridge KM, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland A, Gooding K, Harvey A, Hughes NE, Kuklish SL, Luz JG, Manninen PR, McGee JE, Mudra DR, Navarro A, Norman BH, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, Weller JM, York JS, Yu XP.
Partridge KM, et al. Among authors: sloan av.
Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483. doi: 10.1016/j.bmcl.2016.11.011. Epub 2016 Nov 7.
Bioorg Med Chem Lett. 2017.
PMID: 28190634
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Parathyroid hormone and bisphosphonate have opposite effects on stress fracture repair.
Sloan AV, Martin JR, Li S, Li J.
Sloan AV, et al.
Bone. 2010 Aug;47(2):235-40. doi: 10.1016/j.bone.2010.05.015. Epub 2010 May 16.
Bone. 2010.
PMID: 20580684
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