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Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).
Ho JD, Lee MR, Rauch CT, Aznavour K, Park JS, Luz JG, Antonysamy S, Condon B, Maletic M, Zhang A, Hickey MJ, Hughes NE, Chandrasekhar S, Sloan AV, Gooding K, Harvey A, Yu XP, Kahl SD, Norman BH. Ho JD, et al. Among authors: gooding k. Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129800. doi: 10.1016/j.bbagen.2020.129800. Epub 2020 Nov 25. Biochim Biophys Acta Gen Subj. 2021. PMID: 33246032
Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Kuklish SL, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland AJ, Gooding K, Harvey A, Hughes NE, Luz JG, Manninen PR, McGee JE, Navarro A, Norman BH, Partridge KM, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, York JS, Yu XP. Kuklish SL, et al. Among authors: gooding k. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4824-4828. doi: 10.1016/j.bmcl.2016.08.023. Epub 2016 Aug 10. Bioorg Med Chem Lett. 2016. PMID: 27554445
Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Partridge KM, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland A, Gooding K, Harvey A, Hughes NE, Kuklish SL, Luz JG, Manninen PR, McGee JE, Mudra DR, Navarro A, Norman BH, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, Weller JM, York JS, Yu XP. Partridge KM, et al. Among authors: gooding k. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483. doi: 10.1016/j.bmcl.2016.11.011. Epub 2016 Nov 7. Bioorg Med Chem Lett. 2017. PMID: 28190634
Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study.
Aizawa K, Gates PE, Mawson DM, Casanova F, Gooding KM, Hope SV, Goncalves I, Nilsson J, Khan F, Colhoun HM, Natali A, Palombo C, Shore AC. Aizawa K, et al. Among authors: gooding km. J Appl Physiol (1985). 2024 Jan 1;136(1):13-22. doi: 10.1152/japplphysiol.00283.2023. Epub 2023 Nov 16. J Appl Physiol (1985). 2024. PMID: 37969084 Free article.
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease.
Dwivedi OP, Barreiro K, Käräjämäki A, Valo E, Giri AK, Prasad RB, Roy RD, Thorn LM, Rannikko A, Holthöfer H, Gooding KM, Sourbron S, Delic D, Gomez MF; iBEAt; Groop PH, Tuomi T, Forsblom C, Groop L, Puhka M. Dwivedi OP, et al. Among authors: gooding km. iScience. 2023 Apr 18;26(5):106686. doi: 10.1016/j.isci.2023.106686. eCollection 2023 May 19. iScience. 2023. PMID: 37216114 Free PMC article.
Facilitating high quality acute care in resource-constrained environments: Perspectives of patients recovering from sepsis, their caregivers and healthcare workers in Uganda and Malawi.
Limbani F, Kabajaasi O, Basemera M, Gooding K, Kenya-Mugisha N, Mkandawire M, Rusoke D, Jacob ST, Katahoire AR, Rylance J; African Research Collaboration on Sepsis, Patient Experience Study Group. Limbani F, et al. Among authors: gooding k. PLOS Glob Public Health. 2022 Aug 15;2(8):e0000272. doi: 10.1371/journal.pgph.0000272. eCollection 2022. PLOS Glob Public Health. 2022. PMID: 36962705 Free PMC article.
86 results