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Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with "short" and "long" inverse agonists.
Yu MC, Yang F, Ding XY, Sun NN, Jiang ZY, Huang YF, Yan YR, Zhu C, Xie Q, Chen ZF, Guo SQ, Jiang HL, Chen KX, Luo C, Luo XM, Chen SJ, Wang YH. Yu MC, et al. Among authors: yang f. Acta Pharmacol Sin. 2021 Sep;42(9):1524-1534. doi: 10.1038/s41401-020-00552-w. Epub 2020 Nov 25. Acta Pharmacol Sin. 2021. PMID: 33239687 Free PMC article.
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Sun Z, Zhang H, Zhang Y, Liao L, Zhou W, Zhang F, Lian F, Huang J, Xu P, Zhang R, Lu W, Zhu M, Tao H, Yang F, Ding H, Chen S, Yue L, Zhou B, Zhang N, Tan M, Jiang H, Chen K, Liu B, Liu C, Dang Y, Luo C. Sun Z, et al. Among authors: yang f. Adv Sci (Weinh). 2020 May 13;7(14):2000098. doi: 10.1002/advs.202000098. eCollection 2020 Jul. Adv Sci (Weinh). 2020. PMID: 32714746 Free PMC article.
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain.
Lu T, Lu H, Duan Z, Wang J, Han J, Xiao S, Chen H, Jiang H, Chen Y, Yang F, Li Q, Chen D, Lin J, Li B, Jiang H, Chen K, Lu W, Lin H, Luo C. Lu T, et al. Among authors: yang f. J Med Chem. 2021 Aug 26;64(16):12075-12088. doi: 10.1021/acs.jmedchem.1c00721. Epub 2021 Aug 10. J Med Chem. 2021. PMID: 34375106
High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases.
Xiao S, Guo S, Han J, Sun Y, Wang M, Chen Y, Fang X, Yang F, Mu Y, Zhang L, Ding Y, Zhang N, Jiang H, Chen K, Zhao K, Luo C, Chen S. Xiao S, et al. Among authors: yang f. Nucleic Acids Res. 2022 Jan 25;50(2):e9. doi: 10.1093/nar/gkab989. Nucleic Acids Res. 2022. PMID: 34718755 Free PMC article.
22,033 results
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