Osman EY - Search Results

1

Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy.

Rietz A, Hodgetts KJ, Lusic H, Quist KM, Osman EY, Lorson CL, Androphy EJ. Rietz A, et al. Among authors: osman ey. Life Sci Alliance. 2020 Nov 24;4(1):e202000889. doi: 10.26508/lsa.202000889. Print 2021 Jan. Life Sci Alliance. 2020. PMID: 33234679 Free PMC article.

2

Intraperitoneal delivery of a novel drug-like compound improves disease severity in severe and intermediate mouse models of Spinal Muscular Atrophy.

Osman EY, Rietz A, Kline RA, Cherry JJ, Hodgetts KJ, Lorson CL, Androphy EJ. Osman EY, et al. Sci Rep. 2019 Feb 7;9(1):1633. doi: 10.1038/s41598-018-38208-9. Sci Rep. 2019. PMID: 30733501 Free PMC article.

3

Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy.

Baughan TD, Dickson A, Osman EY, Lorson CL. Baughan TD, et al. Among authors: osman ey. Hum Mol Genet. 2009 May 1;18(9):1600-11. doi: 10.1093/hmg/ddp076. Epub 2009 Feb 19. Hum Mol Genet. 2009. PMID: 19228773 Free PMC article.

4

Bifunctional RNAs targeting the intronic splicing silencer N1 increase SMN levels and reduce disease severity in an animal model of spinal muscular atrophy.

Osman EY, Yen PF, Lorson CL. Osman EY, et al. Mol Ther. 2012 Jan;20(1):119-26. doi: 10.1038/mt.2011.232. Epub 2011 Oct 25. Mol Ther. 2012. PMID: 22031236 Free PMC article.

5

Development and characterization of an SMN2-based intermediate mouse model of Spinal Muscular Atrophy.

Cobb MS, Rose FF, Rindt H, Glascock JJ, Shababi M, Miller MR, Osman EY, Yen PF, Garcia ML, Martin BR, Wetz MJ, Mazzasette C, Feng Z, Ko CP, Lorson CL. Cobb MS, et al. Among authors: osman ey. Hum Mol Genet. 2013 May 1;22(9):1843-55. doi: 10.1093/hmg/ddt037. Epub 2013 Feb 5. Hum Mol Genet. 2013. PMID: 23390132

6

Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds.

Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ. Cherry JJ, et al. Among authors: osman ey. EMBO Mol Med. 2013 Jul;5(7):1103-18. doi: 10.1002/emmm.201202305. Epub 2013 Jun 5. EMBO Mol Med. 2013. PMID: 23740718 Free PMC article.

7

Defining the therapeutic window in a severe animal model of spinal muscular atrophy.

Robbins KL, Glascock JJ, Osman EY, Miller MR, Lorson CL. Robbins KL, et al. Among authors: osman ey. Hum Mol Genet. 2014 Sep 1;23(17):4559-68. doi: 10.1093/hmg/ddu169. Epub 2014 Apr 9. Hum Mol Genet. 2014. PMID: 24722206 Free PMC article.

8

Placental development in a mouse model of spinal muscular atrophy.

Van Gronigen Caesar G, Dale JM, Osman EY, Garcia ML, Lorson CL, Schulz LC. Van Gronigen Caesar G, et al. Among authors: osman ey. Biochem Biophys Res Commun. 2016 Jan 29;470(1):82-87. doi: 10.1016/j.bbrc.2015.12.120. Epub 2015 Dec 31. Biochem Biophys Res Commun. 2016. PMID: 26748185 Free PMC article.

9

Plastin-3 extends survival and reduces severity in mouse models of spinal muscular atrophy.

Kaifer KA, Villalón E, Osman EY, Glascock JJ, Arnold LL, Cornelison DDW, Lorson CL. Kaifer KA, et al. Among authors: osman ey. JCI Insight. 2017 Mar 9;2(5):e89970. doi: 10.1172/jci.insight.89970. JCI Insight. 2017. PMID: 28289706 Free PMC article.

10

Analysis of Azithromycin Monohydrate as a Single or a Combinatorial Therapy in a Mouse Model of Severe Spinal Muscular Atrophy.

Osman EY, Washington CW, Simon ME, Megiddo D, Greif H, Lorson CL. Osman EY, et al. J Neuromuscul Dis. 2017;4(3):237-249. doi: 10.3233/JND-170230. J Neuromuscul Dis. 2017. PMID: 28598854

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