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Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity.
Eur J Med Chem. 2024 Mar 15;268:116202. doi: 10.1016/j.ejmech.2024.116202. Epub 2024 Feb 6.
Eur J Med Chem. 2024.
PMID: 38394929
Free article.
Discovery of novel SARS-CoV-2 inhibitors targeting the main protease Mpro by virtual screenings and hit optimization.
Mercorelli B, Desantis J, Celegato M, Bazzacco A, Siragusa L, Benedetti P, Eleuteri M, Croci F, Cruciani G, Goracci L, Loregian A.
Mercorelli B, et al. Among authors: bazzacco a.
Antiviral Res. 2022 Aug;204:105350. doi: 10.1016/j.antiviral.2022.105350. Epub 2022 Jun 7.
Antiviral Res. 2022.
PMID: 35688349
Free PMC article.
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Indomethacin-based PROTACs as pan-coronavirus antiviral agents.
Desantis J, Mercorelli B, Celegato M, Croci F, Bazzacco A, Baroni M, Siragusa L, Cruciani G, Loregian A, Goracci L.
Desantis J, et al. Among authors: bazzacco a.
Eur J Med Chem. 2021 Dec 15;226:113814. doi: 10.1016/j.ejmech.2021.113814. Epub 2021 Sep 4.
Eur J Med Chem. 2021.
PMID: 34534839
Free PMC article.
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On the production of ancient Egyptian blue: Multi-modal characterization and micron-scale luminescence mapping.
Seymour LM, Nicola M, Kessler MI, Yost CL, Bazzacco A, Marello A, Ferraris E, Gobetto R, Masic A.
Seymour LM, et al. Among authors: bazzacco a.
PLoS One. 2020 Nov 24;15(11):e0242549. doi: 10.1371/journal.pone.0242549. eCollection 2020.
PLoS One. 2020.
PMID: 33232351
Free PMC article.
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