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Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Cree BAC, Cutter G, Wolinsky JS, Freedman MS, Comi G, Giovannoni G, Hartung HP, Arnold D, Kuhle J, Block V, Munschauer FE, Sedel F, Lublin FD; SPI2 investigative teams. Cree BAC, et al. Among authors: kuhle j. Lancet Neurol. 2020 Dec;19(12):988-997. doi: 10.1016/S1474-4422(20)30347-1. Epub 2020 Oct 23. Lancet Neurol. 2020. PMID: 33222767 Clinical Trial.
Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study.
Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, Limmroth V, Polman CH, Schmierer K, Yousry TA, Yang M, Eraksoy M, Meluzinova E, Rektor I, Dawson KT, Sandrock AW, O'Neill GN; BG-12 Phase IIb Study Investigators. Kappos L, et al. Lancet. 2008 Oct 25;372(9648):1463-72. doi: 10.1016/S0140-6736(08)61619-0. Lancet. 2008. PMID: 18970976 Clinical Trial.
Cerebrospinal fluid biomarkers in multiple sclerosis.
Tumani H, Hartung HP, Hemmer B, Teunissen C, Deisenhammer F, Giovannoni G, Zettl UK; BioMS Study Group. Tumani H, et al. Neurobiol Dis. 2009 Aug;35(2):117-27. doi: 10.1016/j.nbd.2009.04.010. Epub 2009 May 5. Neurobiol Dis. 2009. PMID: 19426803 Review.
A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking.
Teunissen CE, Petzold A, Bennett JL, Berven FS, Brundin L, Comabella M, Franciotta D, Frederiksen JL, Fleming JO, Furlan R, Hintzen RQ, Hughes SG, Johnson MH, Krasulova E, Kuhle J, Magnone MC, Rajda C, Rejdak K, Schmidt HK, van Pesch V, Waubant E, Wolf C, Giovannoni G, Hemmer B, Tumani H, Deisenhammer F. Teunissen CE, et al. Among authors: kuhle j. Neurology. 2009 Dec 1;73(22):1914-22. doi: 10.1212/WNL.0b013e3181c47cc2. Neurology. 2009. PMID: 19949037 Free PMC article.
Evidence for acute neurotoxicity after chemotherapy.
Petzold A, Mondria T, Kuhle J, Rocca MA, Cornelissen J, te Boekhorst P, Lowenberg B, Giovannoni G, Filippi M, Kappos L, Hintzen R. Petzold A, et al. Among authors: kuhle j. Ann Neurol. 2010 Dec;68(6):806-15. doi: 10.1002/ana.22169. Ann Neurol. 2010. PMID: 21194151
452 results