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Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.
Kasashima H, Duran A, Martinez-Ordoñez A, Nakanishi Y, Kinoshita H, Linares JF, Reina-Campos M, Kudo Y, L'Hermitte A, Yashiro M, Ohira M, Bao F, Tauriello DVF, Batlle E, Diaz-Meco MT, Moscat J. Kasashima H, et al. Among authors: linares jf. Dev Cell. 2021 Jan 11;56(1):95-110.e10. doi: 10.1016/j.devcel.2020.10.014. Epub 2020 Nov 17. Dev Cell. 2021. PMID: 33207226 Free PMC article.
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Linares JF, Zhang X, Martinez-Ordoñez A, Duran A, Kinoshita H, Kasashima H, Nakanishi N, Nakanishi Y, Carelli R, Cappelli L, Arias E, Yashiro M, Ohira M, Patel S, Inghirami G, Loda M, Cuervo AM, Diaz-Meco MT, Moscat J. Linares JF, et al. Mol Cell. 2021 Nov 4;81(21):4509-4526.e10. doi: 10.1016/j.molcel.2021.08.039. Epub 2021 Sep 23. Mol Cell. 2021. PMID: 34560002 Free PMC article.
The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62.
Linares JF, Cid-Diaz T, Duran A, Osrodek M, Martinez-Ordoñez A, Reina-Campos M, Kuo HH, Elemento O, Martin ML, Cordes T, Thompson TC, Metallo CM, Moscat J, Diaz-Meco MT. Linares JF, et al. Cell Rep. 2022 May 10;39(6):110792. doi: 10.1016/j.celrep.2022.110792. Cell Rep. 2022. PMID: 35545049 Free PMC article.
c-Myc phosphorylation by PKCζ represses prostate tumorigenesis.
Kim JY, Valencia T, Abu-Baker S, Linares J, Lee SJ, Yajima T, Chen J, Eroshkin A, Castilla EA, Brill LM, Medvedovic M, Leitges M, Moscat J, Diaz-Meco MT. Kim JY, et al. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6418-23. doi: 10.1073/pnas.1221799110. Epub 2013 Apr 2. Proc Natl Acad Sci U S A. 2013. PMID: 23550155 Free PMC article.
p62 is a key regulator of nutrient sensing in the mTORC1 pathway.
Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT. Duran A, et al. Among authors: linares jf. Mol Cell. 2011 Oct 7;44(1):134-46. doi: 10.1016/j.molcel.2011.06.038. Mol Cell. 2011. PMID: 21981924 Free PMC article.
44 results