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Peripherally selective diphenyl purine antagonist of the CB1 receptor.
Fulp A, Bortoff K, Zhang Y, Snyder R, Fennell T, Marusich JA, Wiley JL, Seltzman H, Maitra R. Fulp A, et al. Among authors: maitra r. J Med Chem. 2013 Oct 24;56(20):8066-72. doi: 10.1021/jm401129n. Epub 2013 Sep 27. J Med Chem. 2013. PMID: 24041123 Free PMC article.
Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile.
Kormos CM, Gichinga MG, Maitra R, Runyon SP, Thomas JB, Brieaddy LE, Mascarella SW, Navarro HA, Carroll FI. Kormos CM, et al. Among authors: maitra r. J Med Chem. 2014 Sep 11;57(17):7367-81. doi: 10.1021/jm5008177. Epub 2014 Aug 25. J Med Chem. 2014. PMID: 25133923 Free PMC article.
Pyrazole antagonists of the CB1 receptor with reduced brain penetration.
Fulp A, Zhang Y, Bortoff K, Seltzman H, Snyder R, Wiethe R, Amato G, Maitra R. Fulp A, et al. Among authors: maitra r. Bioorg Med Chem. 2016 Mar 1;24(5):1063-70. doi: 10.1016/j.bmc.2016.01.033. Epub 2016 Jan 18. Bioorg Med Chem. 2016. PMID: 26827137 Free PMC article.
224 results