Mirams GR - Search Results

1

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk.

Davies MR, Martinec M, Walls R, Schwarz R, Mirams GR, Wang K, Steiner G, Surinach A, Flores C, Lavé T, Singer T, Polonchuk L. Davies MR, et al. Among authors: mirams gr. Cell Rep Med. 2020 Aug 25;1(5):100076. doi: 10.1016/j.xcrm.2020.100076. eCollection 2020 Aug 25. Cell Rep Med. 2020. PMID: 33205069 Free PMC article.

2

Nuanced Interactions between AKAP79 and STIM1 with Orai1 Ca²⁺ Channels at Endoplasmic Reticulum-Plasma Membrane Junctions Sustain NFAT Activation.

Lin YP, Scappini E, Landaverde C, Parekh-Glitsch F, Tucker CJ, Mirams GR, Parekh AB. Lin YP, et al. Among authors: mirams gr. Mol Cell Biol. 2022 Nov 17;42(11):e0017522. doi: 10.1128/mcb.00175-22. Epub 2022 Nov 1. Mol Cell Biol. 2022. PMID: 36317924 Free PMC article.

3

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings.

Clark AP, Clerx M, Wei S, Lei CL, de Boer TP, Mirams GR, Christini DJ, Krogh-Madsen T. Clark AP, et al. Among authors: mirams gr. Europace. 2023 Aug 2;25(9):euad243. doi: 10.1093/europace/euad243. Europace. 2023. PMID: 37552789 Free PMC article.

4

Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.

Mirams GR, Davies MR, Cui Y, Kohl P, Noble D. Mirams GR, et al. Br J Pharmacol. 2012 Nov;167(5):932-45. doi: 10.1111/j.1476-5381.2012.02020.x. Br J Pharmacol. 2012. PMID: 22568589 Free PMC article. Review.

5

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.

Elkins RC, Davies MR, Brough SJ, Gavaghan DJ, Cui Y, Abi-Gerges N, Mirams GR. Elkins RC, et al. Among authors: mirams gr. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):112-22. doi: 10.1016/j.vascn.2013.04.007. Epub 2013 May 5. J Pharmacol Toxicol Methods. 2013. PMID: 23651875 Free PMC article.

6

Prediction of Thorough QT study results using action potential simulations based on ion channel screens.

Mirams GR, Davies MR, Brough SJ, Bridgland-Taylor MH, Cui Y, Gavaghan DJ, Abi-Gerges N. Mirams GR, et al. J Pharmacol Toxicol Methods. 2014 Nov-Dec;70(3):246-54. doi: 10.1016/j.vascn.2014.07.002. Epub 2014 Jul 31. J Pharmacol Toxicol Methods. 2014. PMID: 25087753 Free PMC article.

7

Recent developments in using mechanistic cardiac modelling for drug safety evaluation.

Davies MR, Wang K, Mirams GR, Caruso A, Noble D, Walz A, Lavé T, Schuler F, Singer T, Polonchuk L. Davies MR, et al. Among authors: mirams gr. Drug Discov Today. 2016 Jun;21(6):924-38. doi: 10.1016/j.drudis.2016.02.003. Epub 2016 Feb 15. Drug Discov Today. 2016. PMID: 26891981 Free PMC article. Review.

8

Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology.

Lei CL, Wang K, Clerx M, Johnstone RH, Hortigon-Vinagre MP, Zamora V, Allan A, Smith GL, Gavaghan DJ, Mirams GR, Polonchuk L. Lei CL, et al. Among authors: mirams gr. Front Physiol. 2017 Dec 12;8:986. doi: 10.3389/fphys.2017.00986. eCollection 2017. Front Physiol. 2017. PMID: 29311950 Free PMC article.

9

Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System.

Lei CL, Clerx M, Gavaghan DJ, Polonchuk L, Mirams GR, Wang K. Lei CL, et al. Among authors: mirams gr. Biophys J. 2019 Dec 17;117(12):2438-2454. doi: 10.1016/j.bpj.2019.07.029. Epub 2019 Jul 25. Biophys J. 2019. PMID: 31447109 Free PMC article.

10

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence.

Lei CL, Clerx M, Beattie KA, Melgari D, Hancox JC, Gavaghan DJ, Polonchuk L, Wang K, Mirams GR. Lei CL, et al. Among authors: mirams gr. Biophys J. 2019 Dec 17;117(12):2455-2470. doi: 10.1016/j.bpj.2019.07.030. Epub 2019 Jul 25. Biophys J. 2019. PMID: 31451180 Free PMC article.

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