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Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect.
Ibrahim TS, Hawwas MM, Malebari AM, Taher ES, Omar AM, Neamatallah T, Abdel-Samii ZK, Safo MK, Elshaier YAMM. Ibrahim TS, et al. Among authors: omar am. J Enzyme Inhib Med Chem. 2021 Dec;36(1):802-818. doi: 10.1080/14756366.2021.1899168. J Enzyme Inhib Med Chem. 2021. PMID: 33730937 Free PMC article.
Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.
Huang B, Ghatge MS, Donkor AK, Musayev FN, Deshpande TM, Al-Awadh M, Alhashimi RT, Zhu H, Omar AM, Telen MJ, Zhang Y, McMahon TJ, Abdulmalik O, Safo MK. Huang B, et al. Among authors: omar am. Molecules. 2022 Oct 12;27(20):6835. doi: 10.3390/molecules27206835. Molecules. 2022. PMID: 36296435 Free PMC article.
Exploring the dual effect of novel 1,4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms.
Malebari AM, E A Ahmed H, Ihmaid SK, Omar AM, Muhammad YA, Althagfan SS, Aljuhani N, A A El-Sayed AA, Halawa AH, El-Tahir HM, Turkistani SA, Almaghrabi M, K B Aljohani A, El-Agrody AM, Abulkhair HS. Malebari AM, et al. Among authors: omar am. Bioorg Chem. 2023 Jan;130:106255. doi: 10.1016/j.bioorg.2022.106255. Epub 2022 Nov 17. Bioorg Chem. 2023. PMID: 36403336 Free PMC article.
A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses.
Khayat MT, Ahmed HEA, Omar AM, Muhammad YA, Mohammad KA, Malebari AM, Khayyat AN, Halawa AH, Abulkhair HS, Al-Karmalawy AA, Almaghrabi M, Alharbi M, Aljahdali AS, El-Agrody AM. Khayat MT, et al. Among authors: omar am. J Biomol Struct Dyn. 2023;41(24):15243-15261. doi: 10.1080/07391102.2023.2188957. Epub 2023 Mar 13. J Biomol Struct Dyn. 2023. PMID: 36914238
226 results