Brohus M - Search Results

1

Infanticide vs. inherited cardiac arrhythmias.

Brohus M, Arsov T, Wallace DA, Jensen HH, Nyegaard M, Crotti L, Adamski M, Zhang Y, Field MA, Athanasopoulos V, Baró I, Ribeiro de Oliveira-Mendes BB, Redon R, Charpentier F, Raju H, DiSilvestre D, Wei J, Wang R, Rafehi H, Kaspi A, Bahlo M, Dick IE, Chen SRW, Cook MC, Vinuesa CG, Overgaard MT, Schwartz PJ. Brohus M, et al. Europace. 2021 Mar 8;23(3):441-450. doi: 10.1093/europace/euaa272. Europace. 2021. PMID: 33200177 Free PMC article.

2

The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.

Brohus M, Gorbunova V, Faulkes CG, Overgaard MT, Conover CA. Brohus M, et al. PLoS One. 2015 Dec 22;10(12):e0145587. doi: 10.1371/journal.pone.0145587. eCollection 2015. PLoS One. 2015. PMID: 26694858 Free PMC article.

3

Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients.

Bieghs L, Brohus M, Kristensen IB, Abildgaard N, Bøgsted M, Johnsen HE, Conover CA, De Bruyne E, Vanderkerken K, Overgaard MT, Nyegaard M. Bieghs L, et al. Among authors: brohus m. PLoS One. 2016 Apr 25;11(4):e0154256. doi: 10.1371/journal.pone.0154256. eCollection 2016. PLoS One. 2016. PMID: 27111220 Free PMC article.

4

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.

Wang K, Holt C, Lu J, Brohus M, Larsen KT, Overgaard MT, Wimmer R, Van Petegem F. Wang K, et al. Among authors: brohus m. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10556-E10565. doi: 10.1073/pnas.1808733115. Epub 2018 Oct 22. Proc Natl Acad Sci U S A. 2018. PMID: 30348784 Free PMC article.

5

Human Calmodulin Mutations.

Jensen HH, Brohus M, Nyegaard M, Overgaard MT. Jensen HH, et al. Among authors: brohus m. Front Mol Neurosci. 2018 Nov 13;11:396. doi: 10.3389/fnmol.2018.00396. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30483049 Free PMC article.

6

Ca²⁺-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains.

Brohus M, Søndergaard MT, Wayne Chen SR, van Petegem F, Overgaard MT. Brohus M, et al. Biochem J. 2019 Jan 18;476(2):193-209. doi: 10.1042/BCJ20180545. Biochem J. 2019. PMID: 30530841 Free PMC article.

7

Diminished inhibition and facilitated activation of RyR2-mediated Ca²⁺ release is a common defect of arrhythmogenic calmodulin mutations.

Søndergaard MT, Liu Y, Brohus M, Guo W, Nani A, Carvajal C, Fill M, Overgaard MT, Chen SRW. Søndergaard MT, et al. Among authors: brohus m. FEBS J. 2019 Nov;286(22):4554-4578. doi: 10.1111/febs.14969. Epub 2019 Jul 12. FEBS J. 2019. PMID: 31230402 Free article.

8

Role of cardiac ryanodine receptor calmodulin-binding domains in mediating the action of arrhythmogenic calmodulin N-domain mutation N54I.

Søndergaard MT, Liu Y, Guo W, Wei J, Wang R, Brohus M, Overgaard MT, Chen SRW. Søndergaard MT, et al. Among authors: brohus m. FEBS J. 2020 Jun;287(11):2256-2280. doi: 10.1111/febs.15147. Epub 2019 Dec 18. FEBS J. 2020. PMID: 31763755 Free article.

9

Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca²⁺ binding and cause misfolding.

Wang K, Brohus M, Holt C, Overgaard MT, Wimmer R, Van Petegem F. Wang K, et al. Among authors: brohus m. J Physiol. 2020 Mar;598(6):1169-1186. doi: 10.1113/JP279307. Epub 2020 Feb 18. J Physiol. 2020. PMID: 32012279 Free article.

10

The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor.

Holt C, Hamborg L, Lau K, Brohus M, Sørensen AB, Larsen KT, Sommer C, Van Petegem F, Overgaard MT, Wimmer R. Holt C, et al. Among authors: brohus m. J Biol Chem. 2020 May 29;295(22):7620-7634. doi: 10.1074/jbc.RA120.013430. Epub 2020 Apr 21. J Biol Chem. 2020. PMID: 32317284 Free PMC article.

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