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TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.
Carey KL, Paulus GLC, Wang L, Balce DR, Luo JW, Bergman P, Ferder IC, Kong L, Renaud N, Singh S, Kost-Alimova M, Nyfeler B, Lassen KG, Virgin HW, Xavier RJ. Carey KL, et al. Among authors: singh s. Cell Rep. 2020 Nov 10;33(6):108371. doi: 10.1016/j.celrep.2020.108371. Cell Rep. 2020. PMID: 33176151 Free PMC article.
Predicting cell health phenotypes using image-based morphology profiling.
Way GP, Kost-Alimova M, Shibue T, Harrington WF, Gill S, Piccioni F, Becker T, Shafqat-Abbasi H, Hahn WC, Carpenter AE, Vazquez F, Singh S. Way GP, et al. Among authors: singh s. Mol Biol Cell. 2021 Apr 19;32(9):995-1005. doi: 10.1091/mbc.E20-12-0784. Epub 2021 Feb 3. Mol Biol Cell. 2021. PMID: 33534641 Free PMC article.
Morphology and gene expression profiling provide complementary information for mapping cell state.
Way GP, Natoli T, Adeboye A, Litichevskiy L, Yang A, Lu X, Caicedo JC, Cimini BA, Karhohs K, Logan DJ, Rohban MH, Kost-Alimova M, Hartland K, Bornholdt M, Chandrasekaran SN, Haghighi M, Weisbart E, Singh S, Subramanian A, Carpenter AE. Way GP, et al. Among authors: singh s. Cell Syst. 2022 Nov 16;13(11):911-923.e9. doi: 10.1016/j.cels.2022.10.001. Epub 2022 Oct 28. Cell Syst. 2022. PMID: 36395727 Free PMC article.
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A. Wieder N, et al. Among authors: singh s. Cell Metab. 2023 May 2;35(5):887-905.e11. doi: 10.1016/j.cmet.2023.03.018. Epub 2023 Apr 18. Cell Metab. 2023. PMID: 37075753 Free PMC article.
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations.
Chandrasekaran SN, Cimini BA, Goodale A, Miller L, Kost-Alimova M, Jamali N, Doench JG, Fritchman B, Skepner A, Melanson M, Kalinin AA, Arevalo J, Haghighi M, Caicedo JC, Kuhn D, Hernandez D, Berstler J, Shafqat-Abbasi H, Root DE, Swalley SE, Garg S, Singh S, Carpenter AE. Chandrasekaran SN, et al. Among authors: singh s. Nat Methods. 2024 Apr 9. doi: 10.1038/s41592-024-02241-6. Online ahead of print. Nat Methods. 2024. PMID: 38594452
Cell Painting predicts impact of lung cancer variants.
Caicedo JC, Arevalo J, Piccioni F, Bray MA, Hartland CL, Wu X, Brooks AN, Berger AH, Boehm JS, Carpenter AE, Singh S. Caicedo JC, et al. Among authors: singh s. Mol Biol Cell. 2022 May 15;33(6):ar49. doi: 10.1091/mbc.E21-11-0538. Epub 2022 Mar 30. Mol Biol Cell. 2022. PMID: 35353015 Free PMC article.
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter J, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A. Wieder N, et al. Among authors: singh s. bioRxiv [Preprint]. 2023 Feb 20:2023.02.19.529127. doi: 10.1101/2023.02.19.529127. bioRxiv. 2023. PMID: 36865221 Free PMC article. Updated. Preprint.
Optimizing the Cell Painting assay for image-based profiling.
Cimini BA, Chandrasekaran SN, Kost-Alimova M, Miller L, Goodale A, Fritchman B, Byrne P, Garg S, Jamali N, Logan DJ, Concannon JB, Lardeau CH, Mouchet E, Singh S, Shafqat Abbasi H, Aspesi P Jr, Boyd JD, Gilbert T, Gnutt D, Hariharan S, Hernandez D, Hormel G, Juhani K, Melanson M, Mervin LH, Monteverde T, Pilling JE, Skepner A, Swalley SE, Vrcic A, Weisbart E, Williams G, Yu S, Zapiec B, Carpenter AE. Cimini BA, et al. Among authors: singh s. Nat Protoc. 2023 Jul;18(7):1981-2013. doi: 10.1038/s41596-023-00840-9. Epub 2023 Jun 21. Nat Protoc. 2023. PMID: 37344608 Review.
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