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Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections.
Eapen MS, Lu W, Hackett TL, Singhera GK, Thompson IE, McAlinden KD, Hardikar A, Weber HC, Haug G, Wark PAB, Chia C, Sohal SS. Eapen MS, et al. Among authors: wark pab. Am J Physiol Lung Cell Mol Physiol. 2021 Jan 1;320(1):L158-L163. doi: 10.1152/ajplung.00437.2020. Epub 2020 Nov 11. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33174446 Free PMC article.
Antiviral immunity is impaired in COPD patients with frequent exacerbations.
Singanayagam A, Loo SL, Calderazzo M, Finney LJ, Trujillo Torralbo MB, Bakhsoliani E, Girkin J, Veerati P, Pathinayake PS, Nichol KS, Reid A, Footitt J, Wark PAB, Grainge CL, Johnston SL, Bartlett NW, Mallia P. Singanayagam A, et al. Among authors: wark pab. Am J Physiol Lung Cell Mol Physiol. 2019 Dec 1;317(6):L893-L903. doi: 10.1152/ajplung.00253.2019. Epub 2019 Sep 12. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 31513433 Free PMC article.
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma.
Wark PAB, Pathinayake PS, Kaiko G, Nichol K, Ali A, Chen L, Sutanto EN, Garratt LW, Sohal SS, Lu W, Eapen MS, Oldmeadow C, Bartlett N, Reid A, Veerati P, Hsu AC, Looi K, Iosifidis T, Stick SM, Hansbro PM, Kicic A. Wark PAB, et al. Respirology. 2021 May;26(5):442-451. doi: 10.1111/resp.14003. Epub 2021 Jan 17. Respirology. 2021. PMID: 33455043 Free PMC article.
Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing.
Johansen MD, Mahbub RM, Idrees S, Nguyen DH, Miemczyk S, Pathinayake P, Nichol K, Hansbro NG, Gearing LJ, Hertzog PJ, Gallego-Ortega D, Britton WJ, Saunders BM, Wark PA, Faiz A, Hansbro PM. Johansen MD, et al. Am J Respir Crit Care Med. 2022 Sep 15;206(6):712-729. doi: 10.1164/rccm.202108-1901OC. Am J Respir Crit Care Med. 2022. PMID: 35549656 Free PMC article.
Adverse roles of mast cell chymase-1 in COPD.
Liu G, Jarnicki AG, Paudel KR, Lu W, Wadhwa R, Philp AM, Van Eeckhoutte H, Marshall JE, Malyla V, Katsifis A, Fricker M, Hansbro NG, Dua K, Kermani NZ, Eapen MS, Tiotiu A, Chung KF, Caramori G, Bracke K, Adcock IM, Sohal SS, Wark PA, Oliver BG, Hansbro PM. Liu G, et al. Eur Respir J. 2022 Dec 8;60(6):2101431. doi: 10.1183/13993003.01431-2021. Print 2022 Dec. Eur Respir J. 2022. PMID: 35777766
Differential airway remodeling changes were observed in patients with asthma COPD overlap compared to patients with asthma and COPD alone.
Dey S, Lu W, Weber HC, Young S, Larby J, Chia C, Haug G, Brake SJ, Myers S, Gaikwad AV, Bhattarai P, Pathinayake PS, Wark PAB, Eapen MS, Sohal SS. Dey S, et al. Among authors: wark pab. Am J Physiol Lung Cell Mol Physiol. 2022 Oct 1;323(4):L473-L483. doi: 10.1152/ajplung.00137.2022. Epub 2022 Aug 23. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35997281 Free PMC article.
The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi.
Chan LLY, Anderson DE, Cheng HS, Ivan FX, Chen S, Kang AEZ, Foo R, Gamage AM, Tiew PY, Koh MS, Lee KCH, Nichol K, Pathinayake PS, Chan YL, Yeo TW, Oliver BG, Wark PAB, Liu L, Tan NS, Wang LF, Chotirmall SH. Chan LLY, et al. Among authors: wark pab. Nat Commun. 2022 Dec 10;13(1):7635. doi: 10.1038/s41467-022-35253-x. Nat Commun. 2022. PMID: 36496442 Free PMC article.
271 results