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Broad genic repression domains signify enhanced silencing of oncogenes.
Zhao D, Zhang L, Zhang M, Xia B, Lv J, Gao X, Wang G, Meng Q, Yi Y, Zhu S, Tomoiaga AS, Lee MG, Cooke JP, Cao Q, Chen K. Zhao D, et al. Among authors: chen k. Nat Commun. 2020 Nov 3;11(1):5560. doi: 10.1038/s41467-020-18913-8. Nat Commun. 2020. PMID: 33144558 Free PMC article.
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.
Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z, Tennen RI, Paredes S, Young NL, Chen K, Struhl K, Garcia BA, Gozani O, Li W, Chua KF. Barber MF, et al. Among authors: chen k. Nature. 2012 Jul 5;487(7405):114-8. doi: 10.1038/nature11043. Nature. 2012. PMID: 22722849 Free PMC article.
An essential role for UTX in resolution and activation of bivalent promoters.
Dhar SS, Lee SH, Chen K, Zhu G, Oh W, Allton K, Gafni O, Kim YZ, Tomoiga AS, Barton MC, Hanna JH, Wang Z, Li W, Lee MG. Dhar SS, et al. Among authors: chen k. Nucleic Acids Res. 2016 May 5;44(8):3659-74. doi: 10.1093/nar/gkv1516. Epub 2016 Jan 13. Nucleic Acids Res. 2016. PMID: 26762983 Free PMC article.
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