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Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine.
Mori T, Takemura Y, Arima T, Iwase Y, Narita M, Miyano K, Hamada Y, Suda Y, Matsuzawa A, Sugita K, Matsumura S, Sasaki S, Yamauchi T, Higashiyama K, Uezono Y, Yamazaki M, Kuzumaki N, Narita M. Mori T, et al. Among authors: uezono y. Biochem Biophys Res Commun. 2021 Jan 1;534:988-994. doi: 10.1016/j.bbrc.2020.10.053. Epub 2020 Nov 1. Biochem Biophys Res Commun. 2021. PMID: 33139013
Usefulness for the combination of G-protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance.
Mori T, Kuzumaki N, Arima T, Narita M, Tateishi R, Kondo T, Hamada Y, Kuwata H, Kawata M, Yamazaki M, Sugita K, Matsuzawa A, Baba K, Yamauchi T, Higashiyama K, Nonaka M, Miyano K, Uezono Y, Narita M. Mori T, et al. Among authors: uezono y. Mol Pain. 2017 Jan-Dec;13:1744806917740030. doi: 10.1177/1744806917740030. Mol Pain. 2017. PMID: 29056067 Free PMC article.
Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state.
Narita M, Imai S, Nakamura A, Ozeki A, Asato M, Rahmadi M, Sudo Y, Hojo M, Uezono Y, Devi LA, Kuzumaki N, Suzuki T. Narita M, et al. Among authors: uezono y. Addict Biol. 2013 Jul;18(4):614-22. doi: 10.1111/j.1369-1600.2011.00354.x. Epub 2011 Aug 4. Addict Biol. 2013. PMID: 21812868 Free PMC article.
[Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state].
Satoshi I, Narita M, Ozeki A, Nakamura A, Hashimoto S, Narita M, Kuzumaki N, Uezono Y, Suzuki T. Satoshi I, et al. Among authors: uezono y. Nihon Shinkei Seishin Yakurigaku Zasshi. 2008 Nov;28(5-6):169-76. Nihon Shinkei Seishin Yakurigaku Zasshi. 2008. PMID: 19108502 Review. Japanese.
245 results