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Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium; Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M. Rozman J, et al. Nat Commun. 2018 Jan 18;9(1):288. doi: 10.1038/s41467-017-01995-2. Nat Commun. 2018. PMID: 29348434 Free PMC article.
Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.
Kaklamanos A, Rozman J, Roulis M, Karagianni N, Armaka M, Wu M, Brachthäuser L, Calzada-Wack J, Horsch M, Beckers J, Rathkolb B, Adler T, Neff F, Wolf E, Gailus-Durner V, Fuchs H, de Angelis MH, Kollias G. Kaklamanos A, et al. Among authors: wu m. Sci Rep. 2017 May 25;7(1):2397. doi: 10.1038/s41598-017-02581-8. Sci Rep. 2017. PMID: 28546545 Free PMC article.
Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
Fuchs H, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, Cho YL, Garrett L, Hölter SM, Irmler M, Kistler M, Kraiger M, Mayer-Kuckuk P, Moreth K, Rathkolb B, Rozman J, da Silva Buttkus P, Treise I, Zimprich A, Gampe K, Hutterer C, Stöger C, Leuchtenberger S, Maier H, Miller M, Scheideler A, Wu M, Beckers J, Bekeredjian R, Brielmeier M, Busch DH, Klingenspor M, Klopstock T, Ollert M, Schmidt-Weber C, Stöger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Gailus-Durner V, Hrabě de Angelis M. Fuchs H, et al. Among authors: wu m. Behav Brain Res. 2018 Oct 15;352:187-196. doi: 10.1016/j.bbr.2017.09.048. Epub 2017 Sep 29. Behav Brain Res. 2018. PMID: 28966146 Review.
Liver adapts mitochondrial function to insulin resistant and diabetic states in mice.
Franko A, von Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stoehr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, de Angelis MH, Paulsson M, Schubert M, Wiesner RJ. Franko A, et al. Among authors: wu m. J Hepatol. 2014 Apr;60(4):816-23. doi: 10.1016/j.jhep.2013.11.020. Epub 2013 Nov 28. J Hepatol. 2014. PMID: 24291365
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
Schriever SC, Kabra DG, Pfuhlmann K, Baumann P, Baumgart EV, Nagler J, Seebacher F, Harrison L, Irmler M, Kullmann S, Corrêa-da-Silva F, Giesert F, Jain R, Schug H, Castel J, Martinez S, Wu M, Häring HU, de Angelis MH, Beckers J, Müller TD, Stemmer K, Wurst W, Rozman J, Nogueiras R, De Angelis M, Molkentin JD, Krahmer N, Yi CX, Schmidt MV, Luquet S, Heni M, Tschöp MH, Pfluger PT. Schriever SC, et al. Among authors: wu m. J Clin Invest. 2020 Nov 2;130(11):6093-6108. doi: 10.1172/JCI136363. J Clin Invest. 2020. PMID: 32780722 Free PMC article.
High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice.
Kahle M, Schäfer A, Seelig A, Schultheiß J, Wu M, Aichler M, Leonhardt J, Rathkolb B, Rozman J, Sarioglu H, Hauck SM, Ueffing M, Wolf E, Kastenmueller G, Adamski J, Walch A, Hrabé de Angelis M, Neschen S. Kahle M, et al. Among authors: wu m. Mol Metab. 2014 Nov 14;4(1):39-50. doi: 10.1016/j.molmet.2014.11.004. eCollection 2015 Jan. Mol Metab. 2014. PMID: 25685688 Free PMC article.
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