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The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover.
Garzón-Tituaña M, Arias MA, Sierra-Monzón JL, Morte-Romea E, Santiago L, Ramirez-Labrada A, Martinez-Lostao L, Paño-Pardo JR, Galvez EM, Pardo J. Garzón-Tituaña M, et al. Front Immunol. 2020 Jun 17;11:1054. doi: 10.3389/fimmu.2020.01054. eCollection 2020. Front Immunol. 2020. PMID: 32655547 Free PMC article. Review.
All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity.
Ramírez-Labrada A, Pesini C, Santiago L, Hidalgo S, Calvo-Pérez A, Oñate C, Andrés-Tovar A, Garzón-Tituaña M, Uranga-Murillo I, Arias MA, Galvez EM, Pardo J. Ramírez-Labrada A, et al. Front Immunol. 2022 May 16;13:896228. doi: 10.3389/fimmu.2022.896228. eCollection 2022. Front Immunol. 2022. PMID: 35651603 Free PMC article. Review.
Adoptive NK Cell Transfer as a Treatment in Colorectal Cancer Patients: Analyses of Tumour Cell Determinants Correlating With Efficacy In Vitro and In Vivo.
Lanuza PM, Alonso MH, Hidalgo S, Uranga-Murillo I, García-Mulero S, Arnau R, Santos C, Sanjuan X, Santiago L, Comas L, Redrado S, Pazo-Cid R, Agustin-Ferrández MJ, Jaime-Sánchez P, Pesini C, Gálvez EM, Ramírez-Labrada A, Arias M, Sanz-Pamplona R, Pardo J. Lanuza PM, et al. Among authors: ramirez labrada a. Front Immunol. 2022 Jun 7;13:890836. doi: 10.3389/fimmu.2022.890836. eCollection 2022. Front Immunol. 2022. PMID: 35747143 Free PMC article.
PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells.
Pesini C, Hidalgo S, Arias MA, Santiago L, Calvo C, Ocariz-Díez M, Isla D, Lanuza PM, Agustín MJ, Galvez EM, Ramírez-Labrada A, Pardo J. Pesini C, et al. Among authors: ramirez labrada a. Oncoimmunology. 2022 Jul 6;11(1):2096359. doi: 10.1080/2162402X.2022.2096359. eCollection 2022. Oncoimmunology. 2022. PMID: 35813574 Free PMC article.
Integrated analysis of circulating immune cellular and soluble mediators reveals specific COVID19 signatures at hospital admission with utility for prediction of clinical outcomes.
Uranga-Murillo I, Morte E, Hidalgo S, Pesini C, García-Mulero S, Sierra JL, Santiago L, Arias M, De Miguel D, Encabo-Berzosa MDM, Gracia-Tello B, Sanz-Pamplona R, Martinez-Lostao L, Galvez EM, Paño-Pardo JR, Ramirez-Labrada A, Pardo J. Uranga-Murillo I, et al. Theranostics. 2022 Jan 1;12(1):290-306. doi: 10.7150/thno.63463. eCollection 2022. Theranostics. 2022. PMID: 34987646 Free PMC article.
Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.
Santiago L, Castro M, Sanz-Pamplona R, Garzón M, Ramirez-Labrada A, Tapia E, Moreno V, Layunta E, Gil-Gómez G, Garrido M, Peña R, Lanuza PM, Comas L, Jaime-Sanchez P, Uranga-Murillo I, Del Campo R, Pelegrín P, Camerer E, Martínez-Lostao L, Muñoz G, Uranga JA, Alcalde A, Galvez EM, Ferrandez A, Bird PI, Metkar S, Arias MA, Pardo J. Santiago L, et al. Cell Rep. 2020 Jul 7;32(1):107847. doi: 10.1016/j.celrep.2020.107847. Cell Rep. 2020. PMID: 32640217 Free article.
Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis.
Garzón-Tituaña M, Sierra-Monzón JL, Comas L, Santiago L, Khaliulina-Ushakova T, Uranga-Murillo I, Ramirez-Labrada A, Tapia E, Morte-Romea E, Algarate S, Couty L, Camerer E, Bird PI, Seral C, Luque P, Paño-Pardo JR, Galvez EM, Pardo J, Arias M. Garzón-Tituaña M, et al. Theranostics. 2021 Jan 30;11(8):3781-3795. doi: 10.7150/thno.49288. eCollection 2021. Theranostics. 2021. PMID: 33664861 Free PMC article.
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