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Depletion of LAG-3+ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781.
Ellis J, J B Marks D, Srinivasan N, Barrett C, Hopkins TG, Richards A, Fuhr R, Albayaty M, Coenen M, Liefaard L, Leavens K, Nevin KL, Tang S, Hughes SA, Fortunato L, Edwards K, Cui Y, Anselm R, Delves CJ, Charles E, Feeney M, Webb TM, Brett SJ, Schmidt TS, Stone J, Savage COS, Wisniacki N, Tarzi RM. Ellis J, et al. Among authors: hughes sa. Clin Pharmacol Ther. 2021 May;109(5):1293-1303. doi: 10.1002/cpt.2091. Epub 2020 Nov 24. Clin Pharmacol Ther. 2021. PMID: 33113155 Free PMC article. Clinical Trial.
Lymphocyte Activation Gene (LAG)-3 Is Associated With Mucosal Inflammation and Disease Activity in Ulcerative Colitis.
Slevin SM, Garner LC, Lahiff C, Tan M, Wang LM, Ferry H, Greenaway B, Lynch K, Geremia A, Hughes S, Leavens K, Krull D, Marks DJB, Nevin K, Page K, Srinivasan N, Tarzi R, Klenerman P, Travis S, Arancibia-Cárcamo CV, Keshav S. Slevin SM, et al. J Crohns Colitis. 2020 Oct 5;14(10):1446-1461. doi: 10.1093/ecco-jcc/jjaa054. J Crohns Colitis. 2020. PMID: 32179884 Free PMC article.
Oxidative photocatalysis on membranes triggers non-canonical pyroptosis.
Lee C, Park M, Wijesinghe WCB, Na S, Lee CG, Hwang E, Yoon G, Lee JK, Roh DH, Kwon YH, Yang J, Hughes SA, Vince JE, Seo JK, Min D, Kwon TH. Lee C, et al. Among authors: hughes sa. Nat Commun. 2024 May 13;15(1):4025. doi: 10.1038/s41467-024-47634-5. Nat Commun. 2024. PMID: 38740804 Free PMC article.
Mothers' Experiences During the 2022 Infant Formula Shortage in Washington D.C.
Sylvetsky AC, Hughes SA, Kuttamperoor JT, Moore HR, Murphy J, Sacheck J, Smith ER. Sylvetsky AC, et al. Among authors: hughes sa. Matern Child Health J. 2024 May;28(5):873-886. doi: 10.1007/s10995-023-03860-9. Epub 2023 Dec 26. Matern Child Health J. 2024. PMID: 38147276 Free PMC article.
A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation.
Speir M, Tye H, Gottschalk TA, Simpson DS, Djajawi TM, Deo P, Ambrose RL, Conos SA, Emery J, Abraham G, Pascoe A, Hughes SA, Weir A, Hawkins ED, Kong I, Herold MJ, Pearson JS, Lalaoui N, Naderer T, Vince JE, Lawlor KE. Speir M, et al. Among authors: hughes sa. EMBO Rep. 2023 Nov 6;24(11):e56865. doi: 10.15252/embr.202356865. Epub 2023 Oct 17. EMBO Rep. 2023. PMID: 37846472 Free PMC article.
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency.
Hughes SA, Lin M, Weir A, Huang B, Xiong L, Chua NK, Pang J, Santavanond JP, Tixeira R, Doerflinger M, Deng Y, Yu CH, Silke N, Conos SA, Frank D, Simpson DS, Murphy JM, Lawlor KE, Pearson JS, Silke J, Pellegrini M, Herold MJ, Poon IKH, Masters SL, Li M, Tang Q, Zhang Y, Rashidi M, Geng L, Vince JE. Hughes SA, et al. EMBO J. 2023 Mar 1;42(5):e110468. doi: 10.15252/embj.2021110468. Epub 2023 Jan 17. EMBO J. 2023. PMID: 36647737 Free PMC article.
88 results