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The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling.
Sałaciak K, Głuch-Lutwin M, Siwek A, Szafarz M, Kazek G, Bednarski M, Nowiński L, Mitchell E, Jastrzębska-Więsek M, Partyka A, Wesołowska A, Kołaczkowski M, Szkaradek N, Marona H, Sapa J, Pytka K. Sałaciak K, et al. Among authors: kolaczkowski m. J Psychopharmacol. 2020 Dec;34(12):1431-1442. doi: 10.1177/0269881120959605. Epub 2020 Oct 24. J Psychopharmacol. 2020. PMID: 33103555
Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dione.
Obniska J, Pawłowski M, Kołaczkowski M, Czopek A, Duszyńska B, Klodzińska A, Tatarczyńska E, Chojnacka-Wójcik E. Obniska J, et al. Among authors: kolaczkowski m. Pol J Pharmacol. 2003 Jul-Aug;55(4):553-7. Pol J Pharmacol. 2003. PMID: 14581713 Free article.
Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity.
Czopek A, Byrtus H, Kołaczkowski M, Pawłowski M, Dybała M, Nowak G, Tatarczyńska E, Wesołowska A, Chojnacka-Wójcik E. Czopek A, et al. Among authors: kolaczkowski m. Eur J Med Chem. 2010 Apr;45(4):1295-303. doi: 10.1016/j.ejmech.2009.11.053. Epub 2009 Dec 6. Eur J Med Chem. 2010. PMID: 20060623
Antipsychotic, antidepressant, and cognitive-impairment properties of antipsychotics: rat profile and implications for behavioral and psychological symptoms of dementia.
Kołaczkowski M, Mierzejewski P, Bienkowski P, Wesołowska A, Newman-Tancredi A. Kołaczkowski M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2014 Jun;387(6):545-57. doi: 10.1007/s00210-014-0966-4. Epub 2014 Mar 6. Naunyn Schmiedebergs Arch Pharmacol. 2014. PMID: 24599316 Free PMC article.
137 results