Egan TJ - Search Results

1

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.

Horatscheck A, Andrijevic A, Nchinda AT, Le Manach C, Paquet T, Khonde LP, Dam J, Pawar K, Taylor D, Lawrence N, Brunschwig C, Gibhard L, Njoroge M, Reader J, van der Watt M, Wicht K, de Sousa ACC, Okombo J, Maepa K, Egan TJ, Birkholtz LM, Basarab GS, Wittlin S, Fish PV, Street LJ, Duffy J, Chibale K. Horatscheck A, et al. Among authors: egan tj. J Med Chem. 2020 Nov 12;63(21):13013-13030. doi: 10.1021/acs.jmedchem.0c01411. Epub 2020 Oct 25. J Med Chem. 2020. PMID: 33103428 Free PMC article.

2

Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

Egan TJ, Hunter R, Kaschula CH, Marques HM, Misplon A, Walden J. Egan TJ, et al. J Med Chem. 2000 Jan 27;43(2):283-91. doi: 10.1021/jm990437l. J Med Chem. 2000. PMID: 10649984

3

Fate of haem iron in the malaria parasite Plasmodium falciparum.

Egan TJ, Combrinck JM, Egan J, Hearne GR, Marques HM, Ntenteni S, Sewell BT, Smith PJ, Taylor D, van Schalkwyk DA, Walden JC. Egan TJ, et al. Among authors: egan j. Biochem J. 2002 Jul 15;365(Pt 2):343-7. doi: 10.1042/BJ20020793. Biochem J. 2002. PMID: 12033986 Free PMC article.

4

Physico-chemical aspects of hemozoin (malaria pigment) structure and formation.

Egan TJ. Egan TJ. J Inorg Biochem. 2002 Jul 25;91(1):19-26. doi: 10.1016/s0162-0134(02)00372-0. J Inorg Biochem. 2002. PMID: 12121758 Review.

5

Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position.

Kaschula CH, Egan TJ, Hunter R, Basilico N, Parapini S, Taramelli D, Pasini E, Monti D. Kaschula CH, et al. Among authors: egan tj. J Med Chem. 2002 Aug 1;45(16):3531-9. doi: 10.1021/jm020858u. J Med Chem. 2002. PMID: 12139464

6

Discovering antimalarials: a new strategy.

Egan TJ. Egan TJ. Chem Biol. 2002 Aug;9(8):852-3. doi: 10.1016/s1074-5521(02)00196-5. Chem Biol. 2002. PMID: 12204682 Review.

7

Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials.

Egan TJ. Egan TJ. Mini Rev Med Chem. 2001 May;1(1):113-23. doi: 10.2174/1389557013407188. Mini Rev Med Chem. 2001. PMID: 12369996 Review.

8

In vitro antimalarial activity of a series of cationic 2,2'-bipyridyl- and 1,10-phenanthrolineplatinum(II) benzoylthiourea complexes.

Egan TJ, Koch KR, Swan PL, Clarkson C, Van Schalkwyk DA, Smith PJ. Egan TJ, et al. J Med Chem. 2004 May 20;47(11):2926-34. doi: 10.1021/jm031132g. J Med Chem. 2004. PMID: 15139771

9

Haemozoin formation.

Egan TJ. Egan TJ. Mol Biochem Parasitol. 2008 Feb;157(2):127-36. doi: 10.1016/j.molbiopara.2007.11.005. Epub 2007 Nov 17. Mol Biochem Parasitol. 2008. PMID: 18083247 Review.

10

Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity.

October N, Watermeyer ND, Yardley V, Egan TJ, Ncokazi K, Chibale K. October N, et al. Among authors: egan tj. ChemMedChem. 2008 Nov;3(11):1649-53. doi: 10.1002/cmdc.200800172. ChemMedChem. 2008. PMID: 18846586 No abstract available.

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