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Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model.
Justin A, Ashwini P, Jose JA, Jeyarani V, Dhanabal SP, Manisha C, Mandal SP, Bhavimani G, Prabitha P, Yuvaraj S, Prashantha Kumar BR. Justin A, et al. Among authors: prashantha kumar br. Front Neurosci. 2020 Sep 25;14:530148. doi: 10.3389/fnins.2020.530148. eCollection 2020. Front Neurosci. 2020. PMID: 33100954 Free PMC article.
Rational Design, Synthesis, and In Vitro Neuroprotective Evaluation of Novel Glitazones for PGC-1α Activation via PPAR-γ: a New Therapeutic Strategy for Neurodegenerative Disorders.
Justin A, Mandal S, Prabitha P, Dhivya S, Yuvaraj S, Kabadi P, Sekhar SJ, Sandhya CH, Wadhwani AD, Divakar S, Bharathi JJ, Durai P, Prashantha Kumar BR. Justin A, et al. Among authors: prashantha kumar br. Neurotox Res. 2020 Mar;37(3):508-524. doi: 10.1007/s12640-019-00132-9. Epub 2019 Nov 28. Neurotox Res. 2020. PMID: 31782098
Minutes of PPAR-γ agonism and neuroprotection.
Prashantha Kumar BR, Kumar AP, Jose JA, Prabitha P, Yuvaraj S, Chipurupalli S, Jeyarani V, Manisha C, Banerjee S, Jeyabalan JB, Mohankumar SK, Dhanabal SP, Justin A. Prashantha Kumar BR, et al. Neurochem Int. 2020 Nov;140:104814. doi: 10.1016/j.neuint.2020.104814. Epub 2020 Aug 3. Neurochem Int. 2020. PMID: 32758586 Review.
Design, parallel synthesis of Biginelli 1,4-dihydropyrimidines using PTSA as a catalyst, evaluation of anticancer activity and structure activity relationships via 3D QSAR studies.
Faizan S, Prashantha Kumar BR, Lalitha Naishima N, Ashok T, Justin A, Vijay Kumar M, Bistuvalli Chandrashekarappa R, Manjunathaiah Raghavendra N, Kabadi P, Adhikary L. Faizan S, et al. Among authors: prashantha kumar br. Bioorg Chem. 2021 Dec;117:105462. doi: 10.1016/j.bioorg.2021.105462. Epub 2021 Nov 2. Bioorg Chem. 2021. PMID: 34753059
Design, synthesis and glucose uptake activity of some novel glitazones.
Kar K, Krithika U, Mithuna, Basu P, Santhosh Kumar S, Reji A, Prashantha Kumar BR. Kar K, et al. Among authors: prashantha kumar br. Bioorg Chem. 2014 Oct;56:27-33. doi: 10.1016/j.bioorg.2014.05.006. Epub 2014 May 24. Bioorg Chem. 2014. PMID: 24927033
A promising in silico protocol to develop novel PPARγ antagonists as potential anticancer agents: Design, synthesis and experimental validation via PPARγ protein activity and competitive binding assay.
Sivamani Y, Shanmugarajan D, Durai Ananda Kumar T, Faizan S, Channappa B, Naishima NL, Prashantha Kumar BR. Sivamani Y, et al. Among authors: prashantha kumar br. Comput Biol Chem. 2021 Dec;95:107600. doi: 10.1016/j.compbiolchem.2021.107600. Epub 2021 Nov 10. Comput Biol Chem. 2021. PMID: 34794076
Novel derivatives of eugenol as potent anti-inflammatory agents via PPARγ agonism: rational design, synthesis, analysis, PPARγ protein binding assay and computational studies.
Anjum NF, Shanmugarajan D, Shivaraju VK, Faizan S, Naishima NL, Prashantha Kumar BR, Javid S, Purohit MN. Anjum NF, et al. Among authors: prashantha kumar br. RSC Adv. 2022 Jun 7;12(26):16966-16978. doi: 10.1039/d2ra02116a. eCollection 2022 Jun 1. RSC Adv. 2022. PMID: 35754905 Free PMC article.
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