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Population Pharmacokinetic Analysis of BMS-986166, a Novel Selective Sphingosine-1-Phosphate-1 Receptor Modulator, and Exposure-Response Assessment of Lymphocyte Counts and Heart Rate in Healthy Participants.
Bihorel S, Singhal S, Shevell D, Sun H, Xie J, Basdeo S, Liu A, Dutta S, Ludwig E, Huang H, Lin KJ, Fura A, Throup J, Girgis IG. Bihorel S, et al. Among authors: liu a. Clin Pharmacol Drug Dev. 2021 Jan;10(1):8-21. doi: 10.1002/cpdd.878. Epub 2020 Oct 8. Clin Pharmacol Drug Dev. 2021. PMID: 33090733 Free PMC article. Clinical Trial.
Safety, pharmacokinetics and pharmacodynamics of branebrutinib (BMS-986195), a covalent, irreversible inhibitor of Bruton's tyrosine kinase: Randomised phase I, placebo-controlled trial in healthy participants.
Catlett IM, Nowak M, Kundu S, Zheng N, Liu A, He B, Girgis IG, Grasela DM. Catlett IM, et al. Among authors: liu a. Br J Clin Pharmacol. 2020 Sep;86(9):1849-1859. doi: 10.1111/bcp.14290. Epub 2020 Apr 12. Br J Clin Pharmacol. 2020. PMID: 32198939 Free PMC article. Clinical Trial.
Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays.
Wang J, Gu H, Liu A, Kozhich A, Rangan V, Myler H, Luo L, Wong R, Sun H, Wang B, Vezina HE, Deshpande S, Zhang Y, Yang Z, Olah TV, Aubry AF, Arnold ME, Pillutla R, DeSilva B. Wang J, et al. Among authors: liu a. Bioanalysis. 2016 Jul;8(13):1383-401. doi: 10.4155/bio-2016-0017. Epub 2016 Jun 9. Bioanalysis. 2016. PMID: 27277879
In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2'-C-Methylguanosine Prodrug BMS-986094 : Potential Role in Clinical Cardiovascular Toxicity.
Li W, Trouba KJ, Ma L, Kwagh J, Storck C, Zhu Y, Flint O, Humphreys WG, Wang J, Liu A, Wang B, Graziano MJ, Davies MH, Sanderson TP. Li W, et al. Among authors: liu a. Int J Toxicol. 2017 Jan-Feb;36(1):35-49. doi: 10.1177/1091581816683642. Epub 2017 Jan 5. Int J Toxicol. 2017. PMID: 28056568
Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC-MS/MS approach: Assay development, validation, and a case study.
Liu A, Kozhich A, Passmore D, Gu H, Wong R, Zambito F, Rangan VS, Myler H, Aubry AF, Arnold ME, Wang J. Liu A, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:54-62. doi: 10.1016/j.jchromb.2015.08.007. Epub 2015 Aug 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 26310897
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