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A genomic explanation connecting "Mediterranean diet", olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells.
Menendez JA, Papadimitropoulou A, Vellon L, Lupu R. Menendez JA, et al. Among authors: papadimitropoulou a. Eur J Cancer. 2006 Oct;42(15):2425-32. doi: 10.1016/j.ejca.2005.10.016. Epub 2006 Jan 6. Eur J Cancer. 2006. PMID: 16406575
Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer.
Menendez JA, Papadimitropoulou A, Vander Steen T, Cuyàs E, Oza-Gajera BP, Verdura S, Espinoza I, Vellon L, Mehmi I, Lupu R. Menendez JA, et al. Among authors: papadimitropoulou a. Cancers (Basel). 2021 Mar 6;13(5):1132. doi: 10.3390/cancers13051132. Cancers (Basel). 2021. PMID: 33800852 Free PMC article.
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