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Page 1
Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.
Smith AL, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A, Houghton D, Hunt M, Sampson JN, Stamp C, Mallett G, Amarnath S, Leslie J, Oakley F, Wilson L, Baker A, Russell OM, Johnson R, Richardson CA, Gupta B, McCallum I, McDonald SA, Kelly S, Mathers JC, Heer R, Taylor RW, Perkins ND, Turnbull DM, Sansom OJ, Greaves LC. Smith AL, et al. Among authors: mcdonald sa. Nat Cancer. 2020 Oct;1(10):976-989. doi: 10.1038/s43018-020-00112-5. Epub 2020 Sep 21. Nat Cancer. 2020. PMID: 33073241 Free PMC article.
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.
Greaves LC, Preston SL, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D, Leedham SJ, Deheragoda M, Sasieni P, Novelli MR, Jankowski JA, Turnbull DM, Wright NA, McDonald SA. Greaves LC, et al. Among authors: mcdonald sa. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):714-9. doi: 10.1073/pnas.0505903103. Epub 2006 Jan 6. Proc Natl Acad Sci U S A. 2006. PMID: 16407113 Free PMC article.
Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells.
McDonald SA, Greaves LC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Deheragoda M, Leedham SJ, Taylor RW, Lee CY, Preston SL, Lovell M, Hunt T, Elia G, Oukrif D, Harrison R, Novelli MR, Mitchell I, Stoker DL, Turnbull DM, Jankowski JA, Wright NA. McDonald SA, et al. Gastroenterology. 2008 Feb;134(2):500-10. doi: 10.1053/j.gastro.2007.11.035. Epub 2007 Nov 28. Gastroenterology. 2008. PMID: 18242216
Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.
Gutierrez-Gonzalez L, Deheragoda M, Elia G, Leedham SJ, Shankar A, Imber C, Jankowski JA, Turnbull DM, Novelli M, Wright NA, McDonald SA. Gutierrez-Gonzalez L, et al. Among authors: mcdonald sa. J Pathol. 2009 Mar;217(4):489-96. doi: 10.1002/path.2502. J Pathol. 2009. PMID: 19156773
Locating the stem cell niche and tracing hepatocyte lineages in human liver.
Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Taylor G, McDonald SA, Wright NA, Alison MR. Fellous TG, et al. Among authors: mcdonald sa. Hepatology. 2009 May;49(5):1655-63. doi: 10.1002/hep.22791. Hepatology. 2009. PMID: 19309719
A methodological approach to tracing cell lineage in human epithelial tissues.
Fellous TG, McDonald SA, Burkert J, Humphries A, Islam S, De-Alwis NM, Gutierrez-Gonzalez L, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, El-Bahrawy M, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Day CP, Wright NA, Alison MR. Fellous TG, et al. Among authors: mcdonald sa. Stem Cells. 2009 Jun;27(6):1410-20. doi: 10.1002/stem.67. Stem Cells. 2009. PMID: 19489031
Author Correction: Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis.
Smith ALM, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A, Houghton D, Hunt M, Sampson JN, Stamp C, Mallett G, Amarnath S, Leslie J, Oakley F, Wilson L, Baker A, Russell OM, Johnson R, Richardson CA, Gupta B, McCallum I, McDonald SAC, Kelly S, Mathers JC, Heer R, Taylor RW, Perkins ND, Turnbull DM, Sansom OJ, Greaves LC. Smith ALM, et al. Nat Cancer. 2021 Jan;2(1):129. doi: 10.1038/s43018-020-00156-7. Nat Cancer. 2021. PMID: 35121898 No abstract available.
316 results