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Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies.
Panni RZ, Herndon JM, Zuo C, Hegde S, Hogg GD, Knolhoff BL, Breden MA, Li X, Krisnawan VE, Khan SQ, Schwarz JK, Rogers BE, Fields RC, Hawkins WG, Gupta V, DeNardo DG. Panni RZ, et al. Among authors: schwarz jk. Sci Transl Med. 2019 Jul 3;11(499):eaau9240. doi: 10.1126/scitranslmed.aau9240. Sci Transl Med. 2019. PMID: 31270275 Free PMC article.
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer.
Hegde S, Krisnawan VE, Herzog BH, Zuo C, Breden MA, Knolhoff BL, Hogg GD, Tang JP, Baer JM, Mpoy C, Lee KB, Alexander KA, Rogers BE, Murphy KM, Hawkins WG, Fields RC, DeSelm CJ, Schwarz JK, DeNardo DG. Hegde S, et al. Among authors: schwarz jk. Cancer Cell. 2020 Mar 16;37(3):289-307.e9. doi: 10.1016/j.ccell.2020.02.008. Cancer Cell. 2020. PMID: 32183949 Free PMC article.
Radiation therapy for vaginal and perirectal lesions in recurrent ovarian cancer.
Johns EA, Stanley JA, Toboni MD, Schwarz JK, Zhang F, Hagemann AR, Fuh KC, Thaker PH, McCourt CK, Mutch DG, Powell MA, Khabele D, Kuroki LM. Johns EA, et al. Among authors: schwarz jk. Gynecol Oncol Rep. 2021 Jun 9;37:100808. doi: 10.1016/j.gore.2021.100808. eCollection 2021 Aug. Gynecol Oncol Rep. 2021. PMID: 34169134 Free PMC article.
Phase I Trial of Stereotactic MRI-Guided Online Adaptive Radiation Therapy (SMART) for the Treatment of Oligometastatic Ovarian Cancer.
Henke LE, Stanley JA, Robinson C, Srivastava A, Contreras JA, Curcuru A, Green OL, Massad LS, Kuroki L, Fuh K, Hagemann A, Mutch D, McCourt C, Thaker P, Powell M, Markovina S, Grigsby PW, Schwarz JK, Chundury A. Henke LE, et al. Among authors: schwarz jk. Int J Radiat Oncol Biol Phys. 2022 Feb 1;112(2):379-389. doi: 10.1016/j.ijrobp.2021.08.033. Epub 2021 Aug 30. Int J Radiat Oncol Biol Phys. 2022. PMID: 34474109 Clinical Trial.
Genomic Characterization and Therapeutic Targeting of HPV Undetected Cervical Carcinomas.
Ruiz FJ, Sundaresan A, Zhang J, Pedamallu CS, Halle MK, Srinivasasainagendra V, Zhang J, Muhammad N, Stanley J, Markovina S, Tiwari HK, Grigsby PW, Krakstad C, Schwarz JK, Ojesina AI. Ruiz FJ, et al. Among authors: schwarz jk. Cancers (Basel). 2021 Sep 10;13(18):4551. doi: 10.3390/cancers13184551. Cancers (Basel). 2021. PMID: 34572780 Free PMC article.
Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer.
Cui Zhou D, Jayasinghe RG, Chen S, Herndon JM, Iglesia MD, Navale P, Wendl MC, Caravan W, Sato K, Storrs E, Mo CK, Liu J, Southard-Smith AN, Wu Y, Naser Al Deen N, Baer JM, Fulton RS, Wyczalkowski MA, Liu R, Fronick CC, Fulton LA, Shinkle A, Thammavong L, Zhu H, Sun H, Wang LB, Li Y, Zuo C, McMichael JF, Davies SR, Appelbaum EL, Robbins KJ, Chasnoff SE, Yang X, Reeb AN, Oh C, Serasanambati M, Lal P, Varghese R, Mashl JR, Ponce J, Terekhanova NV, Yao L, Wang F, Chen L, Schnaubelt M, Lu RJ, Schwarz JK, Puram SV, Kim AH, Song SK, Shoghi KI, Lau KS, Ju T, Chen K, Chatterjee D, Hawkins WG, Zhang H, Achilefu S, Chheda MG, Oh ST, Gillanders WE, Chen F, DeNardo DG, Fields RC, Ding L. Cui Zhou D, et al. Among authors: schwarz jk. Nat Genet. 2022 Sep;54(9):1390-1405. doi: 10.1038/s41588-022-01157-1. Epub 2022 Aug 22. Nat Genet. 2022. PMID: 35995947 Free PMC article.
Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade.
Lander VE, Belle JI, Kingston NL, Herndon JM, Hogg GD, Liu X, Kang LI, Knolhoff BL, Bogner SJ, Baer JM, Zuo C, Borcherding NC, Lander DP, Mpoy C, Scott J, Zahner M, Rogers BE, Schwarz JK, Kim H, DeNardo DG. Lander VE, et al. Among authors: schwarz jk. Cancer Discov. 2022 Dec 2;12(12):2774-2799. doi: 10.1158/2159-8290.CD-22-0192. Cancer Discov. 2022. PMID: 36165893 Free PMC article.
Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity.
Liu X, Hogg GD, Zuo C, Borcherding NC, Baer JM, Lander VE, Kang LI, Knolhoff BL, Ahmad F, Osterhout RE, Galkin AV, Bruey JM, Carter LL, Mpoy C, Vij KR, Fields RC, Schwarz JK, Park H, Gupta V, DeNardo DG. Liu X, et al. Among authors: schwarz jk. Cancer Cell. 2023 Jun 12;41(6):1073-1090.e12. doi: 10.1016/j.ccell.2023.04.018. Epub 2023 May 25. Cancer Cell. 2023. PMID: 37236195
148 results