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Sphingolipid Pathway as a Source of Vulnerability in IDH1mut Glioma.
Dowdy T, Zhang L, Celiku O, Movva S, Lita A, Ruiz-Rodado V, Gilbert MR, Larion M. Dowdy T, et al. Among authors: zhang l. Cancers (Basel). 2020 Oct 10;12(10):2910. doi: 10.3390/cancers12102910. Cancers (Basel). 2020. PMID: 33050528 Free PMC article.
IDH1 mutations induce organelle defects via dysregulated phospholipids.
Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, Burks C, de Val N, Celiku O, Ruiz-Rodado V, Nicoli ER, Kruhlak M, Andresson T, Das S, Yang C, Schmitt R, Herold-Mende C, Gilbert MR, Prasad PN, Larion M. Lita A, et al. Among authors: zhang l. Nat Commun. 2021 Jan 27;12(1):614. doi: 10.1038/s41467-020-20752-6. Nat Commun. 2021. PMID: 33504762 Free PMC article.
Cysteine is a limiting factor for glioma proliferation and survival.
Ruiz-Rodado V, Dowdy T, Lita A, Kramp T, Zhang M, Jung J, Dios-Esponera A, Zhang L, Herold-Mende CC, Camphausen K, Gilbert MR, Larion M. Ruiz-Rodado V, et al. Among authors: zhang l, zhang m. Mol Oncol. 2022 May;16(9):1777-1794. doi: 10.1002/1878-0261.13148. Epub 2022 Jan 6. Mol Oncol. 2022. PMID: 34856072 Free PMC article.
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