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The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies.
Noto FK, Sangodkar J, Adedeji BT, Moody S, McClain CB, Tong M, Ostertag E, Crawford J, Gao X, Hurst L, O'Connor CM, Hanson EN, Izadmehr S, Tohmé R, Narla J, LeSueur K, Bhattacharya K, Rupani A, Tayeh MK, Innis JW, Galsky MD, Evers BM, DiFeo A, Narla G, Jamling TY. Noto FK, et al. Among authors: ostertag e. PLoS One. 2020 Oct 7;15(10):e0240169. doi: 10.1371/journal.pone.0240169. eCollection 2020. PLoS One. 2020. PMID: 33027304 Free PMC article.
Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts.
Noto FK, Adjan-Steffey V, Tong M, Ravichandran K, Zhang W, Arey A, McClain CB, Ostertag E, Mazhar S, Sangodkar J, DiFeo A, Crawford J, Narla G, Jamling TY. Noto FK, et al. Among authors: ostertag e. Mol Cancer Ther. 2018 Nov;17(11):2481-2489. doi: 10.1158/1535-7163.MCT-18-0156. Epub 2018 Sep 11. Mol Cancer Ther. 2018. PMID: 30206106 Free PMC article.
A rat knockout model implicates TRPC4 in visceral pain sensation.
Westlund KN, Zhang LP, Ma F, Nesemeier R, Ruiz JC, Ostertag EM, Crawford JS, Babinski K, Marcinkiewicz MM. Westlund KN, et al. Among authors: ostertag em. Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. Neuroscience. 2014. PMID: 24388923 Free PMC article.
Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of TSCM-enriched allogeneic CAR-T cells.
Madison BB, Patil D, Richter M, Li X, Tong M, Cranert S, Wang X, Martin R, Xi H, Tan Y, Weiss L, Marquez K, Coronella J, Shedlock DJ, Ostertag EM. Madison BB, et al. Among authors: ostertag em. Mol Ther Nucleic Acids. 2022 Jun 29;29:979-995. doi: 10.1016/j.omtn.2022.06.003. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 36189080 Free PMC article.
Loss of the trpc4 gene is associated with a reduction in cocaine self-administration and reduced spontaneous ventral tegmental area dopamine neuronal activity, without deficits in learning for natural rewards.
Klipec WD, Burrow KR, O'Neill C, Cao JL, Lawyer CR, Ostertag E, Fowler M, Bachtell RK, Illig KR, Cooper DC. Klipec WD, et al. Among authors: ostertag e. Behav Brain Res. 2016 Jun 1;306:117-27. doi: 10.1016/j.bbr.2016.03.027. Epub 2016 Mar 14. Behav Brain Res. 2016. PMID: 26988269
Erratum: Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of TSCM-enriched allogeneic CAR-T cells.
Madison BB, Patil D, Richter M, Li X, Tong M, Cranert S, Wang X, Martin R, Xi H, Tan Y, Weiss L, Marquez K, Coronella J, Shedlock DJ, Ostertag EM. Madison BB, et al. Among authors: ostertag em. Mol Ther Nucleic Acids. 2022 Aug 8;29:329. doi: 10.1016/j.omtn.2022.07.021. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 35994046 Free PMC article.
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