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The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies.
Noto FK, Sangodkar J, Adedeji BT, Moody S, McClain CB, Tong M, Ostertag E, Crawford J, Gao X, Hurst L, O'Connor CM, Hanson EN, Izadmehr S, Tohmé R, Narla J, LeSueur K, Bhattacharya K, Rupani A, Tayeh MK, Innis JW, Galsky MD, Evers BM, DiFeo A, Narla G, Jamling TY. Noto FK, et al. Among authors: mcclain cb. PLoS One. 2020 Oct 7;15(10):e0240169. doi: 10.1371/journal.pone.0240169. eCollection 2020. PLoS One. 2020. PMID: 33027304 Free PMC article.
Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts.
Noto FK, Adjan-Steffey V, Tong M, Ravichandran K, Zhang W, Arey A, McClain CB, Ostertag E, Mazhar S, Sangodkar J, DiFeo A, Crawford J, Narla G, Jamling TY. Noto FK, et al. Among authors: mcclain cb. Mol Cancer Ther. 2018 Nov;17(11):2481-2489. doi: 10.1158/1535-7163.MCT-18-0156. Epub 2018 Sep 11. Mol Cancer Ther. 2018. PMID: 30206106 Free PMC article.
MMP2 and TLRs modulate immune responses in the tumor microenvironment.
Muniz-Bongers LR, McClain CB, Saxena M, Bongers G, Merad M, Bhardwaj N. Muniz-Bongers LR, et al. Among authors: mcclain cb. JCI Insight. 2021 Jun 22;6(12):e144913. doi: 10.1172/jci.insight.144913. JCI Insight. 2021. PMID: 34032639 Free PMC article.
Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors.
Roudko V, Bozkus CC, Orfanelli T, McClain CB, Carr C, O'Donnell T, Chakraborty L, Samstein R, Huang KL, Blank SV, Greenbaum B, Bhardwaj N. Roudko V, et al. Among authors: mcclain cb. Cell. 2020 Dec 10;183(6):1634-1649.e17. doi: 10.1016/j.cell.2020.11.004. Epub 2020 Nov 30. Cell. 2020. PMID: 33259803 Free PMC article.
Combined Vaccination with NY-ESO-1 Protein, Poly-ICLC, and Montanide Improves Humoral and Cellular Immune Responses in Patients with High-Risk Melanoma.
Pavlick A, Blazquez AB, Meseck M, Lattanzi M, Ott PA, Marron TU, Holman RM, Mandeli J, Salazar AM, McClain CB, Gimenez G, Balan S, Gnjatic S, Sabado RL, Bhardwaj N. Pavlick A, et al. Among authors: mcclain cb. Cancer Immunol Res. 2020 Jan;8(1):70-80. doi: 10.1158/2326-6066.CIR-19-0545. Epub 2019 Nov 7. Cancer Immunol Res. 2020. PMID: 31699709 Free PMC article. Clinical Trial.
Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1.
Vabret N, Najburg V, Solovyov A, Gopal R, McClain C, Šulc P, Balan S, Rahou Y, Beauclair G, Chazal M, Varet H, Legendre R, Sismeiro O, Sanchez David RY, Chauveau L, Jouvenet N, Markowitz M, van der Werf S, Schwartz O, Tangy F, Bhardwaj N, Greenbaum BD, Komarova AV. Vabret N, et al. iScience. 2022 Jun 11;25(7):104599. doi: 10.1016/j.isci.2022.104599. eCollection 2022 Jul 15. iScience. 2022. PMID: 35789859 Free PMC article.
SARS-CoV-2: the many pros of targeting PLpro.
McClain CB, Vabret N. McClain CB, et al. Signal Transduct Target Ther. 2020 Oct 6;5(1):223. doi: 10.1038/s41392-020-00335-z. Signal Transduct Target Ther. 2020. PMID: 33024071 Free PMC article. No abstract available.