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59 results

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Page 1
Lack of airway submucosal glands impairs respiratory host defenses.
Ostedgaard LS, Price MP, Whitworth KM, Abou Alaiwa MH, Fischer AJ, Warrier A, Samuel M, Spate LD, Allen PD, Hilkin BM, Romano Ibarra GS, Ortiz Bezara ME, Goodell BJ, Mather SE, Powers LS, Stroik MR, Gansemer ND, Hippee CE, Zarei K, Goeken JA, Businga TR, Hoffman EA, Meyerholz DK, Prather RS, Stoltz DA, Welsh MJ. Ostedgaard LS, et al. Elife. 2020 Oct 7;9:e59653. doi: 10.7554/eLife.59653. Elife. 2020. PMID: 33026343 Free PMC article.
Mucus strands from submucosal glands initiate mucociliary transport of large particles.
Fischer AJ, Pino-Argumedo MI, Hilkin BM, Shanrock CR, Gansemer ND, Chaly AL, Zarei K, Allen PD, Ostedgaard LS, Hoffman EA, Stoltz DA, Welsh MJ, Alaiwa MHA. Fischer AJ, et al. Among authors: ostedgaard ls. JCI Insight. 2019 Jan 10;4(1):e124863. doi: 10.1172/jci.insight.124863. JCI Insight. 2019. PMID: 30626743 Free PMC article.
Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways.
Xie Y, Ostedgaard L, Abou Alaiwa MH, Lu L, Fischer AJ, Stoltz DA. Xie Y, et al. Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S171-S176. doi: 10.1513/AnnalsATS.201805-308AW. Ann Am Thorac Soc. 2018. PMID: 30431346 Free PMC article. Review.
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Abou Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ, Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson GA 4th, Hoffman EA, Chang EH, Zabner J, McCray PB Jr, Prather RS, Meyerholz DK, Welsh MJ. Stoltz DA, et al. Among authors: ostedgaard ls. J Clin Invest. 2013 Jun;123(6):2685-93. doi: 10.1172/JCI68867. Epub 2013 May 8. J Clin Invest. 2013. PMID: 23676501 Free PMC article.
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
Shah VS, Meyerholz DK, Tang XX, Reznikov L, Abou Alaiwa M, Ernst SE, Karp PH, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB Jr, Ostedgaard LS, Stoltz DA, Randak CO, Welsh MJ. Shah VS, et al. Among authors: ostedgaard ls. Science. 2016 Jan 29;351(6272):503-7. doi: 10.1126/science.aad5589. Science. 2016. PMID: 26823428 Free PMC article.
CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.
Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Abou Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, Welsh MJ, Sinn PL, Schaffer DV, Zabner J. Steines B, et al. Among authors: ostedgaard ls. JCI Insight. 2016 Sep 8;1(14):e88728. doi: 10.1172/jci.insight.88728. JCI Insight. 2016. PMID: 27699238 Free PMC article.
Gel-forming mucins form distinct morphologic structures in airways.
Ostedgaard LS, Moninger TO, McMenimen JD, Sawin NM, Parker CP, Thornell IM, Powers LS, Gansemer ND, Bouzek DC, Cook DP, Meyerholz DK, Abou Alaiwa MH, Stoltz DA, Welsh MJ. Ostedgaard LS, et al. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6842-6847. doi: 10.1073/pnas.1703228114. Epub 2017 Jun 12. Proc Natl Acad Sci U S A. 2017. PMID: 28607090 Free PMC article.
Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.
Cooney AL, Singh BK, Loza LM, Thornell IM, Hippee CE, Powers LS, Ostedgaard LS, Meyerholz DK, Wohlford-Lenane C, Stoltz DA, B McCray P Jr, Sinn PL. Cooney AL, et al. Among authors: ostedgaard ls. Nucleic Acids Res. 2018 Oct 12;46(18):9591-9600. doi: 10.1093/nar/gky773. Nucleic Acids Res. 2018. PMID: 30165523 Free PMC article.
Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model.
Zarei K, Stroik MR, Gansemer ND, Thurman AL, Ostedgaard LS, Ernst SE, Thornell IM, Powers LS, Pezzulo AA, Meyerholz DK, Stoltz DA. Zarei K, et al. Among authors: ostedgaard ls. Lab Invest. 2020 Nov;100(11):1388-1399. doi: 10.1038/s41374-020-0474-8. Epub 2020 Jul 27. Lab Invest. 2020. PMID: 32719544 Free PMC article.
59 results