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The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance.
Wijers M, Zanoni P, Liv N, Vos DY, Jäckstein MY, Smit M, Wilbrink S, Wolters JC, van der Veen YT, Huijkman N, Dekker D, Kloosterhuis N, van Dijk TH, Billadeau DD, Kuipers F, Klumperman J, von Eckardstein A, Kuivenhoven JA, van de Sluis B. Wijers M, et al. Among authors: van der veen yt. JCI Insight. 2019 Jun 6;4(11):e126462. doi: 10.1172/jci.insight.126462. eCollection 2019 Jun 6. JCI Insight. 2019. PMID: 31167970 Free PMC article.
A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor.
Rimbert A, Dalila N, Wolters JC, Huijkman N, Smit M, Kloosterhuis N, Riemsma M, van der Veen Y, Singla A, van Dijk F; Biobank-Based Integrative Omics Studies Consortium; Frikke-Schmidt R, Burstein E, Tybjærg-Hansen A, van de Sluis B, Kuivenhoven JA. Rimbert A, et al. Eur Heart J. 2020 Mar 1;41(9):1040-1053. doi: 10.1093/eurheartj/ehz727. Eur Heart J. 2020. PMID: 31630160