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Development of bis-ANS-based modified fluorescence titration assay for IFIT/RNA studies.
Dobieżyńska A, Miszkiewicz J, Darżynkiewicz ZM, Tyras M, Stankiewicz-Drogoń A, Trylska J, Darżynkiewicz E, Grzela R. Dobieżyńska A, et al. Among authors: darzynkiewicz e. Biochem Biophys Res Commun. 2020 Dec 10;533(3):391-396. doi: 10.1016/j.bbrc.2020.09.006. Epub 2020 Sep 20. Biochem Biophys Res Commun. 2020. PMID: 32962861 Free article.
Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics.
Miedziak B, Dobieżyńska A, Darżynkiewicz ZM, Bartkowska J, Miszkiewicz J, Kowalska J, Warminski M, Tyras M, Trylska J, Jemielity J, Darzynkiewicz E, Grzela R. Miedziak B, et al. Among authors: darzynkiewicz e, darzynkiewicz zm. RNA. 2020 Jan;26(1):58-68. doi: 10.1261/rna.073304.119. Epub 2019 Oct 28. RNA. 2020. PMID: 31658992 Free PMC article.
Effect of different N7 substitution of dinucleotide cap analogs on the hydrolytic susceptibility towards scavenger decapping enzymes (DcpS).
Piecyk K, Darzynkiewicz ZM, Jankowska-Anyszka M, Ferenc-Mrozek A, Stepinski J, Darzynkiewicz E, Bojarska E. Piecyk K, et al. Among authors: darzynkiewicz e, darzynkiewicz zm. Biochem Biophys Res Commun. 2015 Aug 14;464(1):89-93. doi: 10.1016/j.bbrc.2015.06.001. Epub 2015 Jun 4. Biochem Biophys Res Commun. 2015. PMID: 26049109
Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety--fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis.
Rydzik AM, Kulis M, Lukaszewicz M, Kowalska J, Zuberek J, Darzynkiewicz ZM, Darzynkiewicz E, Jemielity J. Rydzik AM, et al. Among authors: darzynkiewicz e, darzynkiewicz zm. Bioorg Med Chem. 2012 Mar 1;20(5):1699-710. doi: 10.1016/j.bmc.2012.01.013. Epub 2012 Jan 20. Bioorg Med Chem. 2012. PMID: 22316555
Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential.
Strenkowska M, Grzela R, Majewski M, Wnek K, Kowalska J, Lukaszewicz M, Zuberek J, Darzynkiewicz E, Kuhn AN, Sahin U, Jemielity J. Strenkowska M, et al. Among authors: darzynkiewicz e. Nucleic Acids Res. 2016 Nov 16;44(20):9578-9590. doi: 10.1093/nar/gkw896. Epub 2016 Oct 7. Nucleic Acids Res. 2016. PMID: 27903882 Free PMC article.
The first examples of mRNA cap analogs bearing boranophosphate modification.
Kowalska J, Zuberek J, Darzynkiewicz ZM, Lukaszewicz M, Darzynkiewicz E, Jemielity J. Kowalska J, et al. Among authors: darzynkiewicz e, darzynkiewicz zm. Nucleic Acids Symp Ser (Oxf). 2008;(52):289-90. doi: 10.1093/nass/nrn146. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776367
Insight into the Binding and Hydrolytic Preferences of hNudt16 Based on Nucleotide Diphosphate Substrates.
Chrabąszczewska M, Winiewska-Szajewska M, Ostrowska N, Bojarska E, Stępiński J, Mancewicz Ł, Łukaszewicz M, Trylska J, Taube M, Kozak M, Darżynkiewicz E, Grzela R. Chrabąszczewska M, et al. Among authors: darzynkiewicz e. Int J Mol Sci. 2021 Oct 10;22(20):10929. doi: 10.3390/ijms222010929. Int J Mol Sci. 2021. PMID: 34681586 Free PMC article.
168 results