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Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions.
Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J, Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L, Nakada D, Chen X. Xu L, et al. Among authors: tong w. Nat Cell Biol. 2020 Oct;22(10):1162-1169. doi: 10.1038/s41556-020-00581-x. Epub 2020 Sep 21. Nat Cell Biol. 2020. PMID: 32958856 Free PMC article.
Lnk deficiency partially mitigates hematopoietic stem cell aging.
Bersenev A, Rozenova K, Balcerek J, Jiang J, Wu C, Tong W. Bersenev A, et al. Among authors: tong w. Aging Cell. 2012 Dec;11(6):949-59. doi: 10.1111/j.1474-9726.2012.00862.x. Epub 2012 Aug 27. Aging Cell. 2012. PMID: 22812478 Free PMC article.
CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies.
Lv K, Jiang J, Donaghy R, Riling CR, Cheng Y, Chandra V, Rozenova K, An W, Mohapatra BC, Goetz BT, Pillai V, Han X, Todd EA, Jeschke GR, Langdon WY, Kumar S, Hexner EO, Band H, Tong W. Lv K, et al. Among authors: tong w. Genes Dev. 2017 May 15;31(10):1007-1023. doi: 10.1101/gad.297135.117. Epub 2017 Jun 13. Genes Dev. 2017. PMID: 28611190 Free PMC article.
SIRT1 is downregulated by autophagy in senescence and ageing.
Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL. Xu C, et al. Among authors: tong w. Nat Cell Biol. 2020 Oct;22(10):1170-1179. doi: 10.1038/s41556-020-00579-5. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989246 Free PMC article.
2,697 results