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Hedgehog Signaling and Truncated GLI1 in Cancer.
Doheny D, Manore SG, Wong GL, Lo HW. Doheny D, et al. Among authors: manore sg. Cells. 2020 Sep 17;9(9):2114. doi: 10.3390/cells9092114. Cells. 2020. PMID: 32957513 Free PMC article. Review.
Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis.
Doheny D, Sirkisoon S, Carpenter RL, Aguayo NR, Regua AT, Anguelov M, Manore SG, Arrigo A, Jalboush SA, Wong GL, Yu Y, Wagner CJ, Chan M, Ruiz J, Thomas A, Strowd R, Lin J, Lo HW. Doheny D, et al. Among authors: manore sg. Oncogene. 2020 Oct;39(42):6589-6605. doi: 10.1038/s41388-020-01454-1. Epub 2020 Sep 14. Oncogene. 2020. PMID: 32929154 Free PMC article.
NEDD4 degrades TUSC2 to promote glioblastoma progression.
Rimkus TK, Arrigo AB, Zhu D, Carpenter RL, Sirkisoon S, Doheny D, Regua AT, Wong GL, Manore S, Wagner C, Lin HK, Jin G, Ruiz J, Chan M, Debinski W, Lo HW. Rimkus TK, et al. Cancer Lett. 2022 Apr 10;531:124-135. doi: 10.1016/j.canlet.2022.01.029. Epub 2022 Feb 12. Cancer Lett. 2022. PMID: 35167936 Free PMC article.
TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers.
Regua AT, Aguayo NR, Jalboush SA, Doheny DL, Manore SG, Zhu D, Wong GL, Arrigo A, Wagner CJ, Yu Y, Thomas A, Chan MD, Ruiz J, Jin G, Strowd R, Sun P, Lin J, Lo HW. Regua AT, et al. Among authors: manore sg. Cancers (Basel). 2021 May 12;13(10):2340. doi: 10.3390/cancers13102340. Cancers (Basel). 2021. PMID: 34066153 Free PMC article.
An FDA-Approved Antifungal, Ketoconazole, and Its Novel Derivative Suppress tGLI1-Mediated Breast Cancer Brain Metastasis by Inhibiting the DNA-Binding Activity of Brain Metastasis-Promoting Transcription Factor tGLI1.
Doheny D, Manore S, Sirkisoon SR, Zhu D, Aguayo NR, Harrison A, Najjar M, Anguelov M, Cox AO, Furdui CM, Watabe K, Hollis T, Thomas A, Strowd R, Lo HW. Doheny D, et al. Cancers (Basel). 2022 Aug 31;14(17):4256. doi: 10.3390/cancers14174256. Cancers (Basel). 2022. PMID: 36077791 Free PMC article.
Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastases.
Sirkisoon SR, Wong GL, Aguayo NR, Doheny DL, Zhu D, Regua AT, Arrigo A, Manore SG, Wagner C, Thomas A, Singh R, Xing F, Jin G, Watabe K, Lo HW. Sirkisoon SR, et al. Among authors: manore sg. Cancer Lett. 2022 Aug 1;540:215726. doi: 10.1016/j.canlet.2022.215726. Epub 2022 May 16. Cancer Lett. 2022. PMID: 35589002 Free PMC article.
Design, synthesis and analysis of novel sphingosine kinase-1 inhibitors to improve oral bioavailability.
Butler KJ, Castro AA, Dwyer TS, Hardwick LM, Iacino MC, Manore SG, Mays KM, McGlade CA, Hair LN, Parker EW, Smith MR, Turnow MT, Wilson MR, Woodson SR, Cotham WE, Walla MD, Hurlbert JC, Christian Grattan T. Butler KJ, et al. Among authors: manore sg. Bioorg Med Chem Lett. 2021 Oct 15;50:128329. doi: 10.1016/j.bmcl.2021.128329. Epub 2021 Aug 19. Bioorg Med Chem Lett. 2021. PMID: 34418572 Free PMC article.
Correction: Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis.
Doheny D, Sirkisoon S, Carpenter RL, Aguayo NR, Regua AT, Anguelov M, Manore SG, Arrigo A, Jalboush SA, Wong GL, Yu Y, Wagner CJ, Chan M, Ruiz J, Thomas A, Strowd R, Lin J, Lo HW. Doheny D, et al. Among authors: manore sg. Oncogene. 2024 Apr 27. doi: 10.1038/s41388-024-03046-9. Online ahead of print. Oncogene. 2024. PMID: 38678124 No abstract available.
11 results