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Synovial fluid from end-stage osteoarthritis induces proliferation and fibrosis of articular chondrocytes via MAPK and RhoGTPase signaling.
Housmans BAC, Neefjes M, Surtel DAM, Vitík M, Cremers A, van Rhijn LW, van der Kraan PM, van den Akker GGH, Welting TJM. Housmans BAC, et al. Among authors: neefjes m. Osteoarthritis Cartilage. 2022 Jun;30(6):862-874. doi: 10.1016/j.joca.2021.12.015. Epub 2022 Feb 15. Osteoarthritis Cartilage. 2022. PMID: 35176481 Free article.
Osteoarthritis-Related Inflammation Blocks TGF-β's Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region.
Thielen N, Neefjes M, Wiegertjes R, van den Akker G, Vitters E, van Beuningen H, Blaney Davidson E, Koenders M, van Lent P, van de Loo F, van Caam A, van der Kraan P. Thielen N, et al. Among authors: neefjes m. Int J Mol Sci. 2021 Jul 29;22(15):8124. doi: 10.3390/ijms22158124. Int J Mol Sci. 2021. PMID: 34360888 Free PMC article.
Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes.
Thielen NGM, Neefjes M, Vitters EL, van Beuningen HM, Blom AB, Koenders MI, van Lent PLEM, van de Loo FAJ, Blaney Davidson EN, van Caam APM, van der Kraan PM. Thielen NGM, et al. Among authors: neefjes m. Cells. 2022 Apr 5;11(7):1232. doi: 10.3390/cells11071232. Cells. 2022. PMID: 35406794 Free PMC article.
Direct comparison of non-osteoarthritic and osteoarthritic synovial fluid-induced intracellular chondrocyte signaling and phenotype changes.
Housmans BAC, van den Akker GGH, Neefjes M, Timur UT, Cremers A, Peffers MJ, Caron MMJ, van Rhijn LW, Emans PJ, Boymans TAEJ, Feczko PZ, van der Kraan PM, Welting TJM. Housmans BAC, et al. Among authors: neefjes m. Osteoarthritis Cartilage. 2023 Jan;31(1):60-71. doi: 10.1016/j.joca.2022.09.004. Epub 2022 Sep 21. Osteoarthritis Cartilage. 2023. PMID: 36150677 Free article.
Gas6/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants.
Vago JP, Valdrighi N, Blaney-Davidson EN, Hornikx DLAH, Neefjes M, Barba-Sarasua ME, Thielen NGM, van den Bosch MHJ, van der Kraan PM, Koenders MI, Amaral FA, van de Loo FAJ. Vago JP, et al. Among authors: neefjes m. Pharmaceuticals (Basel). 2023 May 6;16(5):703. doi: 10.3390/ph16050703. Pharmaceuticals (Basel). 2023. PMID: 37242486 Free PMC article.