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The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1.
Batra R, Nelles DA, Roth DM, Krach F, Nutter CA, Tadokoro T, Thomas JD, Sznajder ŁJ, Blue SM, Gutierrez HL, Liu P, Aigner S, Platoshyn O, Miyanohara A, Marsala M, Swanson MS, Yeo GW. Batra R, et al. Among authors: miyanohara a. Nat Biomed Eng. 2021 Feb;5(2):157-168. doi: 10.1038/s41551-020-00607-7. Epub 2020 Sep 14. Nat Biomed Eng. 2021. PMID: 32929188 Free PMC article.
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS.
Bravo-Hernandez M, Tadokoro T, Navarro MR, Platoshyn O, Kobayashi Y, Marsala S, Miyanohara A, Juhas S, Juhasova J, Skalnikova H, Tomori Z, Vanicky I, Studenovska H, Proks V, Chen P, Govea-Perez N, Ditsworth D, Ciacci JD, Gao S, Zhu W, Ahrens ET, Driscoll SP, Glenn TD, McAlonis-Downes M, Da Cruz S, Pfaff SL, Kaspar BK, Cleveland DW, Marsala M. Bravo-Hernandez M, et al. Among authors: miyanohara a. Nat Med. 2020 Jan;26(1):118-130. doi: 10.1038/s41591-019-0674-1. Epub 2019 Dec 23. Nat Med. 2020. PMID: 31873312 Free PMC article.
Subpial Adeno-associated Virus 9 (AAV9) Vector Delivery in Adult Mice.
Tadokoro T, Miyanohara A, Navarro M, Kamizato K, Juhas S, Juhasova J, Marsala S, Platoshyn O, Curtis E, Gabel B, Ciacci J, Lukacova N, Bimbova K, Marsala M. Tadokoro T, et al. Among authors: miyanohara a. J Vis Exp. 2017 Jul 13;(125):55770. doi: 10.3791/55770. J Vis Exp. 2017. PMID: 28745630 Free PMC article.
Precision spinal gene delivery-induced functional switch in nociceptive neurons reverses neuropathic pain.
Tadokoro T, Bravo-Hernandez M, Agashkov K, Kobayashi Y, Platoshyn O, Navarro M, Marsala S, Miyanohara A, Yoshizumi T, Shigyo M, Krotov V, Juhas S, Juhasova J, Nguyen D, Kupcova Skalnikova H, Motlik J, Studenovska H, Proks V, Reddy R, Driscoll SP, Glenn TD, Kemthong T, Malaivijitnond S, Tomori Z, Vanicky I, Kakinohana M, Pfaff SL, Ciacci J, Belan P, Marsala M. Tadokoro T, et al. Among authors: miyanohara a. Mol Ther. 2022 Aug 3;30(8):2722-2745. doi: 10.1016/j.ymthe.2022.04.023. Epub 2022 May 5. Mol Ther. 2022. PMID: 35524407 Free PMC article.
Subpial delivery of adeno-associated virus 9-synapsin-caveolin-1 (AAV9-SynCav1) preserves motor neuron and neuromuscular junction morphology, motor function, delays disease onset, and extends survival in hSOD1G93A mice.
Wang S, Ichinomiya T, Savchenko P, Wang D, Sawada A, Li X, Duong T, Li W, Bonds JA, Kim EJ, Miyanohara A, Roth DM, Patel HH, Patel PM, Tadokoro T, Marsala M, Head BP. Wang S, et al. Among authors: miyanohara a. Theranostics. 2022 Jul 11;12(12):5389-5403. doi: 10.7150/thno.72614. eCollection 2022. Theranostics. 2022. PMID: 35910808 Free PMC article.
Human mutant huntingtin disrupts vocal learning in transgenic songbirds.
Liu WC, Kohn J, Szwed SK, Pariser E, Sepe S, Haripal B, Oshimori N, Marsala M, Miyanohara A, Lee R. Liu WC, et al. Among authors: miyanohara a. Nat Neurosci. 2015 Nov;18(11):1617-22. doi: 10.1038/nn.4133. Epub 2015 Oct 5. Nat Neurosci. 2015. PMID: 26436900
Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs.
Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T Jr, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M. Strnadel J, et al. Among authors: miyanohara a. Sci Transl Med. 2018 May 9;10(440):eaam6651. doi: 10.1126/scitranslmed.aam6651. Sci Transl Med. 2018. PMID: 29743351 Free article.
Survival and differentiation of human embryonic stem cell-derived neural precursors grafted spinally in spinal ischemia-injured rats or in naive immunosuppressed minipigs: a qualitative and quantitative study.
Kakinohana O, Juhasova J, Juhas S, Motlik J, Platoshyn O, Galik J, Hefferan M, Yuan SH, Vidal JG, Carson CT, van Gorp S, Goldberg D, Leerink M, Lazar P, Marsala S, Miyanohara A, Keshavarzi S, Ciacci JD, Marsala M. Kakinohana O, et al. Among authors: miyanohara a. Cell Transplant. 2012;21(12):2603-19. doi: 10.3727/096368912X653200. Epub 2012 Aug 10. Cell Transplant. 2012. PMID: 22889456 Free article.
74 results