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Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB-VCAM-1 axis.
Li Y, Alhendi AMN, Yeh MC, Elahy M, Santiago FS, Deshpande NP, Wu B, Chan E, Inam S, Prado-Lourenco L, Marchand J, Joyce RD, Wilkinson-White LE, Raftery MJ, Zhu M, Adamson SJ, Barnat F, Viaud-Quentric K, Sockler J, Mackay JP, Chang A, Mitchell P, Marcuccio SM, Khachigian LM. Li Y, et al. Among authors: mackay jp. Sci Adv. 2020 Jul 29;6(31):eaaz7815. doi: 10.1126/sciadv.aaz7815. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32923607 Free PMC article.
Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1.
Wilkinson-White L, Gamsjaeger R, Dastmalchi S, Wienert B, Stokes PH, Crossley M, Mackay JP, Matthews JM. Wilkinson-White L, et al. Among authors: mackay jp. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14443-8. doi: 10.1073/pnas.1105898108. Epub 2011 Aug 15. Proc Natl Acad Sci U S A. 2011. PMID: 21844373 Free PMC article.
Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex.
Dastmalchi S, Wilkinson-White L, Kwan AH, Gamsjaeger R, Mackay JP, Matthews JM. Dastmalchi S, et al. Among authors: mackay jp. Protein Sci. 2012 Nov;21(11):1768-74. doi: 10.1002/pro.2153. Epub 2012 Sep 25. Protein Sci. 2012. PMID: 22936624 Free PMC article.
The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.
Wai DCC, Szyszka TN, Campbell AE, Kwong C, Wilkinson-White LE, Silva APG, Low JKK, Kwan AH, Gamsjaeger R, Chalmers JD, Patrick WM, Lu B, Vakoc CR, Blobel GA, Mackay JP. Wai DCC, et al. Among authors: mackay jp. J Biol Chem. 2018 May 11;293(19):7160-7175. doi: 10.1074/jbc.RA117.000678. Epub 2018 Mar 22. J Biol Chem. 2018. PMID: 29567837 Free PMC article.
Cyclic peptides can engage a single binding pocket through highly divergent modes.
Patel K, Walport LJ, Walshe JL, Solomon PD, Low JKK, Tran DH, Mouradian KS, Silva APG, Wilkinson-White L, Norman A, Franck C, Matthews JM, Guss JM, Payne RJ, Passioura T, Suga H, Mackay JP. Patel K, et al. Among authors: mackay jp. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26728-26738. doi: 10.1073/pnas.2003086117. Epub 2020 Oct 12. Proc Natl Acad Sci U S A. 2020. PMID: 33046654 Free PMC article.
226 results