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Polygenic architecture informs potential vulnerability to drug-induced liver injury.
Koido M, Kawakami E, Fukumura J, Noguchi Y, Ohori M, Nio Y, Nicoletti P, Aithal GP, Daly AK, Watkins PB, Anayama H, Dragan Y, Shinozawa T, Takebe T. Koido M, et al. Among authors: shinozawa t. Nat Med. 2020 Oct;26(10):1541-1548. doi: 10.1038/s41591-020-1023-0. Epub 2020 Sep 7. Nat Med. 2020. PMID: 32895570 Free PMC article.
Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids.
Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T. Ouchi R, et al. Among authors: shinozawa t. Cell Metab. 2019 Aug 6;30(2):374-384.e6. doi: 10.1016/j.cmet.2019.05.007. Epub 2019 May 30. Cell Metab. 2019. PMID: 31155493 Free PMC article.
Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes.
Shinozawa T, Nakamura K, Shoji M, Morita M, Kimura M, Furukawa H, Ueda H, Shiramoto M, Matsuguma K, Kaji Y, Ikushima I, Yono M, Liou SY, Nagai H, Nakanishi A, Yamamoto K, Izumo S. Shinozawa T, et al. Stem Cell Reports. 2017 Feb 14;8(2):226-234. doi: 10.1016/j.stemcr.2016.12.014. Epub 2017 Jan 19. Stem Cell Reports. 2017. PMID: 28111276 Free PMC article.
Video-based assessment of drug-induced effects on contractile motion properties using human induced pluripotent stem cell-derived cardiomyocytes.
Okai Y, Matsune K, Yamanaka K, Matsui T, Pfeiffer Kaushik E, Harada K, Kohara H, Miyawaki A, Ozaki H, Wagoner M, Shinozawa T. Okai Y, et al. Among authors: shinozawa t. J Pharmacol Toxicol Methods. 2020 Sep;105:106893. doi: 10.1016/j.vascn.2020.106893. Epub 2020 Jul 1. J Pharmacol Toxicol Methods. 2020. PMID: 32619502
129 results