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Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.
Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ. Asadi Shahmirzadi A, et al. Among authors: wiley cd. Cell Metab. 2020 Sep 1;32(3):447-456.e6. doi: 10.1016/j.cmet.2020.08.004. Cell Metab. 2020. PMID: 32877690 Free PMC article.
SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells.
Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, Artwood R, Alimirah F, Lopez-Dominguez JA, Kuehnemann C, Danielson SR, Basisty N, Kasler HG, Oron TR, Desprez PY, Mooney SD, Gibson BW, Schilling B, Campisi J, Kapahi P. Wiley CD, et al. Cell Rep. 2019 Sep 24;28(13):3329-3337.e5. doi: 10.1016/j.celrep.2019.08.049. Cell Rep. 2019. PMID: 31553904 Free PMC article.
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Among authors: wiley cd. Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038/s42255-020-00305-3. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199924 Free PMC article.
Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Among authors: wiley cd. Nat Metab. 2021 Jan;3(1):120-121. doi: 10.1038/s42255-020-00328-w. Nat Metab. 2021. PMID: 33303985 No abstract available.
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, Alimirah F, Kim DE, Payne T, Rosko A, Aimontche E, Deshpande SM, Neri F, Kuehnemann C, Demaria M, Ramanathan A, Campisi J. Wiley CD, et al. Among authors: wiley s. Cell Metab. 2021 Jun 1;33(6):1124-1136.e5. doi: 10.1016/j.cmet.2021.03.008. Epub 2021 Apr 2. Cell Metab. 2021. PMID: 33811820 Free PMC article.
Cholesterol drives inflammatory senescence.
Kuehnemann C, Wiley CD. Kuehnemann C, et al. Among authors: wiley cd. Nat Metab. 2023 Mar;5(3):355-356. doi: 10.1038/s42255-023-00758-2. Nat Metab. 2023. PMID: 36864207 No abstract available.
38 results