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The SNM1A DNA repair nuclease.
Baddock HT, Yosaatmadja Y, Newman JA, Schofield CJ, Gileadi O, McHugh PJ. Baddock HT, et al. DNA Repair (Amst). 2020 Nov;95:102941. doi: 10.1016/j.dnarep.2020.102941. Epub 2020 Jul 31. DNA Repair (Amst). 2020. PMID: 32866775 Free PMC article. Review.
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.
Doherty W, Dürr EM, Baddock HT, Lee SY, McHugh PJ, Brown T, Senge MO, Scanlan EM, McGouran JF. Doherty W, et al. Among authors: baddock ht. Org Biomol Chem. 2019 Sep 21;17(35):8094-8105. doi: 10.1039/c9ob01133a. Epub 2019 Aug 5. Org Biomol Chem. 2019. PMID: 31380542 Free PMC article.
EXD2 promotes homologous recombination by facilitating DNA end resection.
Broderick R, Nieminuszczy J, Baddock HT, Deshpande R, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W. Broderick R, et al. Among authors: baddock ht. Nat Cell Biol. 2016 Mar;18(3):271-280. doi: 10.1038/ncb3303. Epub 2016 Jan 25. Nat Cell Biol. 2016. PMID: 26807646 Free PMC article.
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification.
Baddock HT, Brolih S, Yosaatmadja Y, Ratnaweera M, Bielinski M, Swift LP, Cruz-Migoni A, Fan H, Keown JR, Walker AP, Morris GM, Grimes JM, Fodor E, Schofield CJ, Gileadi O, McHugh PJ. Baddock HT, et al. Nucleic Acids Res. 2022 Feb 22;50(3):1484-1500. doi: 10.1093/nar/gkab1303. Nucleic Acids Res. 2022. PMID: 35037045 Free PMC article.
Antiviral activity of bone morphogenetic proteins and activins.
Eddowes LA, Al-Hourani K, Ramamurthy N, Frankish J, Baddock HT, Sandor C, Ryan JD, Fusco DN, Arezes J, Giannoulatou E, Boninsegna S, Chevaliez S, Owens BMJ, Sun CC, Fabris P, Giordani MT, Martines D, Vukicevic S, Crowe J, Lin HY, Rehwinkel J, McHugh PJ, Binder M, Babitt JL, Chung RT, Lawless MW, Armitage AE, Webber C, Klenerman P, Drakesmith H. Eddowes LA, et al. Among authors: baddock ht. Nat Microbiol. 2019 Feb;4(2):339-351. doi: 10.1038/s41564-018-0301-9. Epub 2018 Dec 3. Nat Microbiol. 2019. PMID: 30510168 Free PMC article.
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target.
Bielinski M, Henderson LR, Yosaatmadja Y, Swift LP, Baddock HT, Bowen MJ, Brem J, Jones PS, McElroy SP, Morrison A, Speake M, van Boeckel S, van Doornmalen E, van Groningen J, van den Hurk H, Gileadi O, Newman JA, McHugh PJ, Schofield CJ. Bielinski M, et al. Among authors: baddock ht. Chem Sci. 2024 Apr 30;15(21):8227-8241. doi: 10.1039/d4sc00367e. eCollection 2024 May 29. Chem Sci. 2024. PMID: 38817593 Free PMC article.
Structure of the p53 degradation complex from HPV16.
Wang JCK, Baddock HT, Mafi A, Foe IT, Bratkowski M, Lin TY, Jensvold ZD, Preciado López M, Stokoe D, Eaton D, Hao Q, Nile AH. Wang JCK, et al. Among authors: baddock ht. Nat Commun. 2024 Feb 28;15(1):1842. doi: 10.1038/s41467-024-45920-w. Nat Commun. 2024. PMID: 38418456 Free PMC article.
11 results