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The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation.
Wang WM, Liu Z, Liu AJ, Wang YX, Wang HG, An D, Heng B, Xie LH, Duan JL, Liu YQ. Wang WM, et al. Among authors: wang yx, wang hg. CNS Neurosci Ther. 2015 Sep;21(9):708-17. doi: 10.1111/cns.12428. Epub 2015 Jul 20. CNS Neurosci Ther. 2015. PMID: 26190227 Free PMC article.
TPEN, a Specific Zn2+ Chelator, Inhibits Sodium Dithionite and Glucose Deprivation (SDGD)-Induced Neuronal Death by Modulating Apoptosis, Glutamate Signaling, and Voltage-Gated K+ and Na+ Channels.
Zhang F, Ma XL, Wang YX, He CC, Tian K, Wang HG, An D, Heng B, Xie LH, Liu YQ. Zhang F, et al. Among authors: wang yx, wang hg. Cell Mol Neurobiol. 2017 Mar;37(2):235-250. doi: 10.1007/s10571-016-0364-1. Epub 2016 Mar 16. Cell Mol Neurobiol. 2017. PMID: 26983717
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